Effects of flow rate on the migration of different plasticizers from PVC infusion medical devices

PloS One
Lise BernardArmed Study Group

Abstract

Infusion medical devices (MDs) used in hospitals are often made of plasticized polyvinylchloride (PVC). These plasticizers may leach out into infused solutions during clinical practice, especially during risk-situations, e.g multiple infusions in Intensive Care Units and thus may enter into contact with the patients. The migrability of the plasticizers is dependent of several clinical parameters such as temperature, contact time, nature of the simulant, etc… However, no data is available about the influence of the flow rate at which drug solutions are administrated. In this study, we evaluated the impact of different flow rates on the release of the different plasticizers during an infusion procedure in order to assess if they could expose the patients to more toxic amounts of plasticizers. Migration assays with different PVC infusion sets and extension lines were performed with different flow rates that are used in clinical practice during 1h, 2h, 4h, 8h and 24h, using a lipophilic drug simulant. From a clinical point of view, the results showed that, regardless of the plasticizer, the faster the flow rate, the higher the infused volume and the higher the quantities of plasticizers released, both from infusion sets and extensi...Continue Reading

References

Feb 11, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Sandrine Bagel-BoithiasJean Chopineau
Mar 23, 2015·International Journal of Pharmaceutics·L BernardUNKNOWN Armed Study Group
Jul 28, 2015·Toxicology Letters·Raymond M DavidRainer Otter
Aug 19, 2015·International Journal of Pharmaceutics·L BernardUNKNOWN ARMED study group
Nov 13, 2015·Journal of Pharmaceutical and Biomedical Analysis·Daniel BourdeauxUNKNOWN ARMED Study Group
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·H Al SalloumN Yagoubi
Apr 19, 2017·Materials Science & Engineering. C, Materials for Biological Applications·H Al SalloumN Yagoubi

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confocal microscopy

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