Effects of flunarizine on electrical and mechanical responses of smooth muscle cells in basilar and ear arteries of the rabbit

Naunyn-Schmiedeberg's Archives of Pharmacology
T NagaoH Kuriyama

Abstract

The effects of flunarizine on electrical and mechanical responses of smooth muscle tissues of the rabbit basilar and ear arteries to transmural stimulation, high-potassium solution (high-K), 5-hydroxytryptamine and noradrenaline were studied. In the basilar artery, 10(-6) M flunarizine (69 min application) blocked spike potentials generated by outward current stimuli or transmural stimulation without change in the resting-membrane potential or membrane resistance. The spike potentials generated in the ear artery were attenuated by a long exposure (up to 2 h) to a high concentration of flunarizine (10(-6) M). Membrane depolarizations produced by high-K, noradrenaline or 5-hydroxytryptamine were not blocked by flunarizine. Flunarizine inhibited smooth muscle contractions produced by transmural stimuli, high-K, noradrenaline or 5-hydroxytryptamine in both arteries, however the inhibition developed slowly, and the ear artery required a longer period of incubation with flunarizine than the basilar artery. The inhibitory effects of flunarizine on basilar artery were more marked against transmural stimulation or high-K induced contractions than against agonist-induced contractions.

References

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