Effects of flunixin meglumine on postponement of ovulation in mares

American Journal of Veterinary Research
Callum G DonnellyRobert O Gilbert

Abstract

OBJECTIVE To evaluate use of flunixin meglumine as a treatment to postpone ovulation in mares, mare fertility after flunixin meglumine treatment during estrous cycles, and effects of flunixin meglumine on function of the corpus luteum after ovulation. ANIMALS 13 healthy mares. PROCEDURES A single-blinded, placebo-controlled, crossover study was conducted. Flunixin meglumine (1.1 mg/kg, IV, q 24 h) or lactated Ringer solution (placebo treatment) was administered for 2 days to mares with a dominant follicle (≥ 35 mm in diameter) and behavioral signs of estrus. Mares then were bred by artificial insemination. Number of days to ovulation from initial detection of a follicle ≥ 30 mm in diameter, uterine edema score, and pregnancy were determined by ultrasonography; the examiner was unaware of the treatment of each mare. Serum progesterone concentrations were evaluated 5 and 12 days after ovulation by use of radioimmunoassay. RESULTS Data were available for 45 estrus cycles of the 13 mares. Number of days to ovulation from initial detection of a follicle ≥ 30 mm was not significantly affected by administration of flunixin meglumine versus the placebo. Per-cycle pregnancy rate was not significantly different between flunixin meglumine...Continue Reading

References

May 1, 1981·Journal of Reproduction and Fertility·D T Armstrong
Aug 1, 1993·Prostaglandins·W J MurdochL A McPherson
Dec 18, 2001·Animal Reproduction Science·P R Loomis
Dec 18, 2001·Animal Reproduction Science·J C Samper
Nov 17, 2006·Reproduction in Domestic Animals = Zuchthygiene·E HembergS Einarsson
Nov 15, 2008·Reproduction, Fertility, and Development·O J GintherM A Beg
Feb 7, 2013·The Veterinary Journal·Igor F CanissoRobert O Gilbert
May 11, 2013·Journal of Veterinary Pharmacology and Therapeutics·C D Lee, L K Maxwell
Dec 10, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·S T BashirEduardo L Gastal

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