Abstract
A lot of studies have shown that fluoride and aluminum have toxic effect on male reproductive system, but the mechanism of which and the interaction between fluoride and aluminum is still unknown. This study investigated the effects of fluoride (NaF) or/and aluminum (AlCl3) on serum testosterone level, gene and protein expression levels of Steroidogenic Acute Regulatory Protein (StAR) and Cytochrome P450 cholesterol side chain cleavage enzyme (P450scc) in the testes of guinea pigs. Fifty-two guinea pigs were divided randomly into four groups (Control, HiF, HiAl and HiF + HiAl). Fluoride (150 mg NaF/L) or/and aluminum (300 mg AlCl3/L) were orally administrated to male guinea pigs for 13 weeks. The results showed that F and Al reduced number and elevated abnormal ratio of sperm. Meanwhile, the concentrations of serum testosterone in all experimental groups were decreased. P450scc protein expression was significantly reduced in all treatment groups, and StAR expression was decreased remarkably in HiF group and HiF + HiAl group. The levels of StAR mRNA in three groups were reduced by 53.9%, 21.4% and 33.4%, respectively, while the expressions of P450scc mRNA were reduced by 67.8%, 17.0% and 47.8%. Therefore, we concluded that F ind...Continue Reading
References
Oct 1, 1995·Molecular Endocrinology·B J ClarkD M Stocco
Apr 29, 1999·Mechanisms of Ageing and Development·S Leers-SuchetaS Azhar
May 6, 2004·Toxicology·Mokhtar I Yousef
Jul 3, 2004·Endocrinology·Haolin ChenBarry R Zirkin
Jun 30, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·T PushpalathaP Sreenivasula Reddy
Aug 16, 2005·Toxicology·Mokhtar I YousefMervat S Hassan
Apr 10, 2008·Cell Biology and Toxicology·Augustine Arukwe
Mar 17, 2009·Nutrition Research·Abasalt Hosseinzadeh ColagarMohammad Javad Chaichi
Dec 10, 2009·Reproductive Biology·Beata SarosiekJan Glogowski
Jan 7, 2010·Archives of Toxicology·Zilong SunJundong Wang
Jul 24, 2010·Chemico-biological Interactions·Olivier BarbierLuz María Del Razo
Jun 1, 1996·Endocrine·T W Sandhoff, M P McLean
Jan 21, 2011·The Journal of Nutrition·Thomas P CroxfordShannon L Kelleher
Feb 23, 2011·Archives of Toxicology·Zilong SunJundong Wang
Aug 7, 2012·Environmental Toxicology·Zilong SunJundong Wang
Jul 25, 2013·Archives of Toxicology·Zhaojing LuJundong Wang
Sep 21, 2013·Toxicology Letters·Ekambaram PerumalLakshmikanthan Panneerselvam
Aug 21, 2014·The Journal of Clinical Endocrinology and Metabolism·Lanlan FangYing-Pu Sun
Dec 17, 2014·The Journal of Biological Chemistry·Manoj PrasadHimangshu S Bose
Citations
Jul 22, 2016·Chemosphere·Jinling CaoJundong Wang
Nov 26, 2010·Toxicology Letters·Xiaoyan YanJundong Wang
Mar 8, 2017·Journal of Biochemical and Molecular Toxicology·Tianlong HanJundong Wang
Jun 28, 2017·Canadian Journal of Physiology and Pharmacology·Isaac A AdedaraEbenezer O Farombi
May 25, 2020·Andrologia·Vaithinathan SelvarajuRalf Henkel
Sep 2, 2020·Critical Reviews in Toxicology·Robert A Yokel
Sep 19, 2018·Archives of Toxicology·Yangfei ZhaoJundong Wang
Jan 23, 2021·Gene·Zhigang HuXiaolin Liu
Mar 2, 2021·Toxicology Mechanisms and Methods·Priyankar Pal, Prabir Kumar Mukhopadhyay
Nov 11, 2019·Journal of Agricultural and Food Chemistry·Panhong WuJundong Wang
Sep 21, 2017·Journal of Agricultural and Food Chemistry·Jianhai ZhangJundong Wang