Effects of fluorides on Candida albicans

Oral Diseases
S FlisfischT Waltimo

Abstract

To assess whether a short exposure of Candida albicans to commonly used fluorides would affect growth, cell surface hydrophobicity, and adherence to buccal epithelial cells. Candida albicans ATCC 90028 and 11 clinical isolates were used. Minimal inhibitory concentrations (MICs) of sodium fluoride (NaF) and of an amine fluoride / stannous fluoride combination (AmF / SnF2) were determined. Yeasts were exposed to MICs of tested agents for 1 h. Subsequently, their growth was recorded spectrophotometrically. Their cell surface hydrophobicity was assessed with n-hexadecane. Adherence to buccal epithelial cells was determined microscopically. Phosphate buffered saline (PBS) and chlorhexidine digluconate (CHX) served as controls. All results were analyzed by one-way ANOVA. MICs of AmF / SnF(2) and CHX varied between 1 and 4 microg ml(-1), whereas those of NaF were 15 000 microg ml(-1). Statistically significant growth inhibition was detected after AmF / SnF(2) (OD(24 h) +/- SD 0.457 +/- 0.059) and CHX (0.175 +/- 0.065) in comparison with PBS (0.925 +/- 0.087) and NaF (0.813 +/- 0.081). All strains demonstrated uniform behavior. Only minor changes in cell surface hydrophobicity and adherence to buccal epithelial cells (BEC) were detecte...Continue Reading

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Citations

Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·Ghaleb AdwanAli Barakat
Nov 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sanshu LiScott A Strobel
May 2, 2015·The Journal of Advanced Prosthodontics·Burcin OnculFunda Dogruman Al
Apr 11, 2020·Chembiochem : a European Journal of Chemical Biology·Manuel Nieto-Domínguez, Pablo I Nikel
Apr 4, 2021·Polymers·Zbigniew RaszewskiAgnieszka Nowakowska-Toporowska
Jul 28, 2020·Mycopathologia·Rima Zakzuk AlshahniJunji Tagami

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