Effects of fluoroquinolones and glucocorticoids on cultivated tendon cells in vitro

Toxicology in Vitro : an International Journal Published in Association with BIBRA
G KempkaG Schlüter

Abstract

Achilles tendon rupture is known to occur after administration of various drugs to patients. It is also reported to occur after treatment with fluoroquinolone and glucocorticoids. To study potential cytotoxic effects of fluoroquinolones (ciprofloxacin, pefloxacin, sparfloxacin) and triamcinolonacetonide on tendons an in vitro model of cultivated tendon cells (human, dog, mini-pig, rat, marmoset) was established. The cells were characterized by their morphological appearance and by the synthesis of proteoglycans and collagen type I. The cytotoxicity of the tested drugs was determined by measurement of mitochondrial dehydrogenase activity (MTT assay) and other parameters (viability, proteoglycan content, proliferation). These investigations revealed the following: (1) no marked differences were found between various species after ciprofloxacin treatment, only rat tendon cells reacted slightly less sensitively at the highest concentration (100 mug/ml); (2) no age-dependent effects of ciprofloxacin and triamcinolonacetonide were found in cultivated human tendon cells from patients of different ages; (3) the simultaneous administration of fluoroquinolones and triamcinolonacetonide resulted in a significantly greater reduction of cel...Continue Reading

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Citations

Mar 29, 2012·The Tohoku Journal of Experimental Medicine·Ferda Kaleagasioglu, Ercan Olcay
Dec 26, 2009·International Journal of Antimicrobial Agents·Judith SendzikRalf Stahlmann
Jul 15, 2015·BMC Complementary and Alternative Medicine·Catherine BaugéKarim Boumediene
Nov 12, 2016·BMC Musculoskeletal Disorders·Christoph SpangLudvig J Backman
Nov 17, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Tao WangWen Yuan Ding
Oct 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·F PouzaudP Rat
Nov 9, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zhi-Long BaiWen-Yuan Ding
Jun 18, 2020·International Journal of Molecular Sciences·Erman PopowskiGundula Schulze-Tanzil
Jun 21, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Irene BlancoRaymond G Schlienger

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