PMID: 8968448Dec 1, 1996Paper

Effects of fluvastatin on hyperlipidemia after renal transplantation: influence of steroid therapy

The Annals of Pharmacotherapy
J L AustenD E Hricik

Abstract

To assess the efficacy and safety of fluvastatin in hypercholesterolemic, cyclosporine-treated, renal transplant recipients, and to determine whether concomitant steroid therapy in such patients alters the lipid-lowering effects of fluvastatin. An open-label, prospective, parallel study was performed in 20 cyclosporine-treated renal transplant recipients with hypercholesterolemia defined by a low-density lipoprotein (LDL) concentration greater than 160 mg/dL or a total cholesterol/high-density lipoprotein (HDL) concentration ratio greater than 5.0. Lipid profiles were measured before and 1 month after treatment with fluvastatin 20 mg/d. Lipid profiles in a group of patients receiving concomitant therapy with prednisone (n = 12) were compared with those of patients who had not received steroids for at least 6 months (n = 8). The Renal Transplant Clinic at University Hospitals of Cleveland. The main outcome measures were serum concentrations of total cholesterol, LDL, HDL, and triglycerides. Treatment failure was defined by LDL concentrations persistently above 160 mg/dL after 1 month of fluvastatin therapy. Safety was assessed clinically and by serial measurements of liver enzymes and creatine phosphokinase. LDL concentrations d...Continue Reading

Citations

Mar 7, 2018·The Cochrane Database of Systematic Reviews·Stephen P AdamsJames M Wright
Feb 28, 2002·Journal of Clinical Pharmacology·S Appel-DingemanseM Merz
Nov 26, 1999·The Annals of Pharmacotherapy·H C MaltzJ S Cheigh
Feb 13, 2003·Pediatric Transplantation·Elizabeth ArgentFiona E Mackie
Jan 29, 2000·Journal of Clinical Pharmacy and Therapeutics·A Jardine, H Holdaas
Mar 12, 2004·The Journal of Surgical Research·James A Schulak
Oct 24, 1998·Endocrinology and Metabolism Clinics of North America·W T DonahooR H Eckel
Mar 22, 2006·Transplantation Proceedings·M KanbayM Haberal
Aug 24, 2021·Transplantation Proceedings·Yeon-Ho HanSoojinna Choi

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