PMID: 16510377Mar 3, 2006Paper

Effects of fluvastatin treatment on lipid profile, C-reactive protein trend, and renal function in dyslipidemic patients with chronic renal failure

Advances in Therapy
L Di LulloP Polito

Abstract

The purpose of this trial was to evaluate the effects of fluvastatin on the lipid pro-file and on renal function, as measured by creatinine clearance, in dyslipidemic patients with chronic renal failure. In this 8-month prospective, open-label, randomized, parallel-group trial, 130 patients (70 men and 60 women), after a 2-month washout period following previous lipid-lowering treatments, were randomly assigned to fluvastatin XL 80 mg given once daily (80 patients) or to standard treatment (50 patients). Mean total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride values after 3 and 6 months of treatment with fluvastatin showed statistically significant improvement compared with standard treatment. Improved renal function, as measured by creatinine clearance, was observed at the end of the 6-month treatment period in approximately 65% of patients treated with fluvastatin. The increase in creatinine clearance consistently reached 10% to 15% of baseline values. A statistically significant reduction in C-reactive protein (CRP) over baseline values was observed in approximately 75% of patients treated with fluvastatin. Furthermore, mean values of CRP for the fluvast...Continue Reading

References

Sep 28, 1995·The American Journal of Cardiology·W B Kannel
Jul 13, 1995·The American Journal of Cardiology·C J LintottB I Shand
Jun 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P O AttmanP Alaupovic
Jan 1, 1997·International Urology and Nephrology·L LöcseyG Balázs
Feb 13, 1999·Kidney International·J ZimmermannC Wanner
Jul 21, 1999·Kidney International. Supplement·P O AttmanO Samuelsson
Feb 13, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W F KeaneA Agro
May 23, 2001·Clinical Pharmacokinetics·C D Scripture, J A Pieper
Nov 17, 2001·European Journal of Internal Medicine·P L van HaelstJ W Tervaert
Dec 18, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·R BlackburnG Turpin
Jan 5, 2002·Current Atherosclerosis Reports·Christopher C Case, Christie M Ballantyne
Jan 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ola SamuelssonPetar Alaupovic
Feb 22, 2002·Current Opinion in Nephrology and Hypertension·Domenic A Sica, Todd W B Gehr
Feb 28, 2002·Journal of Clinical Pharmacology·S Appel-DingemanseM Merz
May 1, 2002·Current Opinion in Nephrology and Hypertension·Meena Sahadevan, Bertram L Kasiske
Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A AsbergH Holdaas
Jul 31, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Atsuhiro IchiharaTakao Saruta
Dec 6, 2002·Journal of the American Society of Nephrology : JASN·Carmine ZoccaliPietro Finocchiaro
Jun 18, 2004·Drugs·Alberto CorsiniChristie M Ballantyne
Oct 16, 2004·Current Opinion in Nephrology and Hypertension·Colin BaigentMarion Warren
Mar 24, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hallvard HoldaasUNKNOWN ALERT Study Group

❮ Previous
Next ❯

Citations

Oct 13, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Marcello TonelliUNKNOWN Alberta Kidney Disease Network
Oct 28, 2010·Expert Opinion on Pharmacotherapy·Anna GlubaMaciej Banach
Feb 23, 2013·Current Medical Research and Opinion·Dragana NikolicUNKNOWN Lipid and Blood Pressure Meta-Analysis Collaboration Group
Mar 7, 2018·The Cochrane Database of Systematic Reviews·Stephen P AdamsJames M Wright
Jun 1, 2014·The Cochrane Database of Systematic Reviews·Suetonia C PalmerGiovanni F M Strippoli
Jun 2, 2011·Nature Reviews. Nephrology·Vera Krane, Christoph Wanner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.