PMID: 18214123Jan 25, 2008Paper

Effects of folic acid and N-acetylcysteine on plasma homocysteine levels and endothelial function in patients with coronary artery disease

Acta Cardiologica
Hale YilmazOsman Bolca

Abstract

Hyperhomocysteinaemia is related with premature coronary artery disease and adverse cardiac events in patients with coronary artery disease (CAD). It is assumed that hyper-homocysteinaemia causes endothelial dysfunction. In this study, the effect of folic acid and oral N-acetylcysteine (NAC) therapies on plasma homocysteine levels and endothelial function were evaluated in hyperhomocysteinaemic patients with CAD. 60 patients were randomized to either folic acid 5 mg or NAC 600 mg or placebo daily for eight weeks. Brachial artery endothelial functions were studied by using high-resolution ultrasound and assessed by measuring endothelium-dependent dilation (EDD) and endothelium-independent dilation (NEDD). Folic acid and NAC therapies decreased plasma homocysteine (from 21.7 +/- 8.7 micromol/l to 12.5 +/- 2.5 micromol/l, P < 0.001; from 20.9 +/- 7.6 micromol/l to 15.6 +/- 4.3 micromol/l, P = 0.03, respectively), and increased EDD (6.7 +/- 6.1% P = 0.002, 4.4 +/- 2.6% P < 0.001, respectively) compared with placebo. There was no significant difference in improving EDD between the folic acid and the NAC group (6.7 +/- 6.1%, 4.4 +/- 2.6%, P = 0. 168). In the univariate analyses there was an inverse correlation between the post-treatm...Continue Reading

Citations

Dec 4, 2010·Antioxidants & Redox Signaling·Jessica I CohenLaura E Nagy
Dec 21, 2012·Journal of Virology·Katie E CrumpJason M Grayson
Feb 11, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jessica I CohenLaura E Nagy
Feb 12, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·S K CakmakA Kiliç
Feb 28, 2014·Cardiovascular Therapeutics·Balazs Debreceni, Laszlo Debreceni
Mar 3, 2010·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Ron J KeizerPaul Baas
Jan 5, 2018·Nutrition & Metabolism·Avinash KumarSubramanyam N Murthy
Dec 8, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elena Matteucci, Ottavio Giampietro
Jun 9, 2015·Journal of Clinical Pharmacology·Jing WangQiang She

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