Effects of food and gender on the pharmacokinetics of rhein and emodin in rats after oral dosing with Da-Cheng-Qi decoction

Phytotherapy Research : PTR
Han-lin GongXi Huang

Abstract

Da-Cheng-Qi decoction (DCQD), a traditional Chinese medicine preparation used to treat digestive diseases, is composed of dahuang (Rheum officinale Baill, Polygonaceae), houpu (Magnolia officinalis Rehd., Magnoliaceae), zhishi (Citrus aurantium L, Rutaceae) and mangxiao (sodium sulphate). Rhein and emodin are the major active components of Rheum officinale Baill. To investigate the effects of food and gender on the plasma concentrations of rhein and emodin after oral administration of DCQD, a rapid high-performance liquid chromatographic method was developed and validated. A reversed phase C(18) column (150 × 4.6 mm) and a mobile phase of methanol and 0.2% acetic acid (78:22, v/v) were employed with ultraviolet detection at 254 nm. Feeding was observed to decrease the absorption of rhein and emodin in rats receiving DCQD orally. No evidence for gender-based differences in the pharmacokinetics of rhein was observed. However, the half-life and area under the concentration-time curve for emodin differed significantly between male and female rats. Because food intake and gender are anticipated to influence the pharmacokinetics of DCQD in human subjects, it is recommended that oral doses of DCQD be reduced in fasting subjects and th...Continue Reading

References

Jan 1, 1996·Annual Review of Nutrition·P G Welling
Dec 25, 2002·Journal of Ethnopharmacology·Je-Hyun LeeChungsook Kim
Mar 30, 2004·The American Journal of Medicine·Stephen Bent, Richard Ko
Nov 24, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Pavel Drasar, Jitka Moravcova

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Citations

Apr 5, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mei-Ling HouTung-Hu Tsai
Jul 24, 2015·Journal of Pharmaceutical and Biomedical Analysis·Xin DiYouping Liu
Nov 9, 2018·The International Journal of Neuropsychopharmacology·Peng ZengQing Tian
May 4, 2021·Frontiers in Pharmacology·Dongpeng WangXuanbin Wang
Jul 20, 2020·Current Drug Metabolism·Shun-Li XiaoWei Cai

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