Effects of food deprivation on goal-directed behavior, spontaneous locomotion, and c-Fos immunoreactivity in the amygdala.

Behavioural Brain Research
J M MoscarelloA Ettenberg

Abstract

Previous work in our laboratory has shown that food deprivation and food presentation produce different patterns of neuronal activity (as measured by c-Fos immunoreactivity) in the medial prefrontal cortex and nucleus accumbens of rats. Since the amygdala has been implicated in both motivational and reinforcement processes and has neuronal connections to both the prefrontal cortex and nucleus accumbens, it was of interest to assess amygdaloid c-Fos immunoreactivity during similar manipulations of food deprivation and presentation. In the current study, c-Fos counts in both basolateral and central amygdalar nuclei were observed to increase in rats 12- and 36-h food deprived (relative to 0-h controls)-an effect reversed by the presentation of either a small or large meal (2.5 or 20g of food). In another experiment, rats working on a progressive ratio schedule of reinforcement exhibited elevated break-points as a function of food deprivation, a result consistent with the view that the feeding manipulations increased the subjects' level of motivation. In contrast, food deprivation reduced the spontaneous locomotor activity of rats, presumably as a result of an inherent energy-conservation strategy when no food is readily available....Continue Reading

Citations

Oct 21, 2011·Cognitive, Affective & Behavioral Neuroscience·Bettina MaiWolfgang Hauber
Jan 12, 2016·Animals : an Open Access Journal From MDPI·Silke DietzeJörg-Peter Voigt
Jun 3, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Carolina Böettge RosaAlberto A Rasia-Filho
Feb 4, 2012·Behavioural Brain Research·L Valencia-TorresE Szabadi
Mar 1, 2012·Neuron·Joseph LeDoux
Mar 20, 2015·PloS One·Bingjin LiRanji Cui
Aug 7, 2017·Journal of Cellular and Molecular Medicine·Ranji CuiBingjin Li
Apr 6, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Yu FuJianhong Wang

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