Effects of food supplementation on cognitive function, cerebral blood flow, and nutritional status in young children at risk of undernutrition: randomized controlled trial.

BMJ : British Medical Journal
Susan B RobertsPaul Muentener

Abstract

To assess the effects of food supplementation on improving working memory and additional measures including cerebral blood flow in children at risk of undernutrition. Randomized controlled trial. 10 villages in Guinea-Bissau. 1059 children aged 15 months to 7 years; children younger than 4 were the primary population. Supervised isocaloric servings (≈1300 kJ, five mornings each week, 23 weeks) of a new food supplement (NEWSUP, high in plant polyphenols and omega 3 fatty acids, within a wide variety and high fortification of micronutrients, and a high protein content), or a fortified blended food (FBF) used in nutrition programs, or a control meal (traditional rice breakfast). The primary outcome was working memory, a core executive function predicting long term academic achievement. Additional outcomes were hemoglobin concentration, growth, body composition, and index of cerebral blood flow (CBFi). In addition to an intention-to-treat analysis, a predefined per protocol analysis was conducted in children who consumed at least 75% of the supplement (820/925, 89%). The primary outcome was assessed by a multivariable Poisson model; other outcomes were assessed by multivariable linear mixed models. Among children younger than 4, ra...Continue Reading

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Citations

Mar 3, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Marco Ferrari, Valentina Quaresima
Apr 4, 2021·International Journal of Molecular Sciences·Manon LeclercFrédéric Calon
Mar 30, 2021·Frontiers in Psychology·Michael T WilloughbySarah Zimmermann
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lucía Méndez, Isabel Medina

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Methods Mentioned

BETA
infrared spectroscopy

Software Mentioned

SAS
Stata
NEWSUP

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