PMID: 8938823Oct 1, 1996Paper

Effects of footshock stress on regional brain monoamine metabolism and the acquisition of conditioned freezing in rats previously exposed to repeated methamphetamine

Progress in Neuro-psychopharmacology & Biological Psychiatry
K TsuchiyaT Koyama

Abstract

1. Effects of footshock stress on regional brain DA and 5-HT metabolism and the acquisition of conditioned fear in male Wistar-King rats previously exposed to repeated MA were examined. 2. MA-pretreated rats exhibited more freezing than control rats in the conditioned fear test. 3. The HVA levels in the striatum was elevated by footshock only in MA-treated rats but not saline-treated rats. Furthermore, MA-treated rats showed increased metabolism of DA in the mPFC, even when placed in the shock chamber without shocks. 4. The brain serotonergic responsiveness to fear conditioning was also attenuated by repeated administration of MA. 5. These results suggest that not only the brain DA systems but also the brain 5-HT systems play an important role for the development of MA-induced emotional hypersensitivity to stress.

References

Jan 1, 1992·Schizophrenia Bulletin·M SatoT Hamamura
Apr 1, 1988·Behavioral Neuroscience·M S Fanselow, F J Helmstetter
Jan 18, 1980·Science·S M AntelmanD Kocan
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·T InoueI Yamashita
Jun 11, 1993·European Journal of Pharmacology·T Hamamura, H C Fibiger
Apr 1, 1996·Pharmacology, Biochemistry, and Behavior·T InoueT Koyama
Aug 1, 1996·Pharmacology, Biochemistry, and Behavior·K TsuchiyaT Koyama

❮ Previous
Next ❯

Citations

Aug 7, 1999·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·S TakeuchiY Kayama
Oct 25, 2006·Stress : the International Journal on the Biology of Stress·Michael T WilliamsCharles V Vorhees

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.