Effects of fragrance administration on stress-induced prefrontal cortex activity and sebum secretion in the facial skin

Neuroscience Letters
Masahiro TanidaKaoru Sakatani

Abstract

Although fragrances have long been known to influence stress-induced psychosomatic disorders, the neurophysiological mechanism remains unclear. We evaluated the effect of fragrance on the relation between the level of sebum secretion in the facial skin and the stress-induced prefrontal cortex (PFC) activity, which regulates the activity of the hypothalamic-pituitary-adrenal axis. Employing near infrared spectroscopy, we measured hemoglobin concentration changes in the bilateral PFC during a mental arithmetic task in normal adults (n=31), and evaluated asymmetry of the PFC activity in terms of the laterality index (i.e., [(right-left)/(right+left)]) of oxyhemoglobin concentration changes (LI-oxyHb). We measured the level of sebum secretion in the facial skin before the task performance. There was a significant positive correlation between the LI-oxyHb and the level of sebum secretion (r=+0.44, p=0.01). We selected the subjects who exhibited high levels of sebum secretion and right-dominant PFC activity for the study on the fragrance effect (n=12). Administration of fragrance for four weeks significantly reduced the level of sebum (p=0.02) in the fragrance group (n=6). In addition, the LI-oxyHb decreased significantly from 0.11+/...Continue Reading

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Citations

Mar 22, 2012·BioPsychoSocial Medicine·Shinichiro NagamitsuToyojiro Matsuishi
Jun 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Qian-Qian LiLin-Peng Wang
Nov 18, 2008·Hormones and Behavior·Ren-Jen HwangJen-Chuen Hsieh
Oct 15, 2013·International Journal of Cosmetic Science·F L AngelucciH Maibach
Apr 12, 2016·Frontiers in Psychology·Roberta AdorniAngelo Compare
Jun 22, 2013·Chemosphere·Xiaolei ZhangRao Y Surampalli
Aug 12, 2016·Experimental Neurology·Judith K Daniels, Eric Vermetten
Jul 2, 2015·International Journal of Environmental Research and Public Health·Dawou JoungBum-Jin Park
Jan 8, 2019·The British Journal of Dermatology·M MaaroufV Y Shi

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