PMID: 3213426Jan 1, 1988Paper

Effects of free radicals on permeability and vasomotor response of cerebral vessels

Acta Neuropathologica
A UnterbergA Baethmann

Abstract

To obtain further evidence on the role of free radicals as mediators of secondary brain damage, blood-brain barrier (BBB) function and vasomotor response of pial vessels were studied during cortical superfusion of a free radical-generating system of xanthine-oxidase (XO) and hypoxanthine (HX). Intravenously administered Na+-fluorescein (mol. wt. 376), or fluorescein isothiocyanate (FITC)-dextran (mol. wt. 62,000) served as low- and high-molecular weight BBB indicators. Since undialyzed XO considerably increased the osmolarity of artificial cerebrospinal fluid, XO was subjected to equilibrium dialysis, which did not affect enzyme activity. Cortical superfusion with either HX (4 mM) or dialyzed XO alone (0.5 U/ml; osmolarity, 310 mosmol/l) did not induce a vasomotor response. Cortical superfusion with the free radical-generating system under normotonic conditions (HX plus dialyzed XO), led to moderate arterial dilation only with a maximum of +13%. The venous diameters remained unaffected. Moderate extravasation of the low molecular weight indicator Na+-fluorescein was seen in only 33% of the experiments, leakage of FITC-dextran was never observed. To assess the role of hypertonicity of the superfusate, the same experiments were p...Continue Reading

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Citations

Aug 1, 1987·Neurochemical Pathology·R Saunders, L A Horrocks
May 1, 2009·Acta Neuropathologica·Sukriti NagDuncan J Stewart
Dec 9, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R HärtlJ Ghajar
May 31, 2001·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·W G Mayhan
Jan 1, 1990·Journal of Basic and Clinical Physiology and Pharmacology·M WahlL Schilling
Apr 16, 2015·Mediators of Inflammation·Martijn HofmanHans-Christoph Pape
Feb 14, 1998·The British Journal of Surgery·P LintottG Stansby
Oct 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M WahlL Schilling
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K U FrerichsA Baethmann
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad

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