Effects of freezing and cryopreservation on the mechanical properties of arteries

Annals of Biomedical Engineering
Ramji T VenkatasubramanianJohn C Bischof

Abstract

Cryoplasty, a freezing therapy, is being used for the treatment of restenosis in peripheral arteries. In addition, cryo-preserved arteries are increasingly used in vascular grafts. While studies are being performed to establish the efficacy of such treatments, very little is known about the postcryosurgical or postcryo-preservation changes in mechanical properties of the arteries. Few studies have examined the effect of freezing in the absence of cryoprotective agents (CPAs), and the several studies done in the presence of CPAs have given mixed results. To examine this issue further, we froze pig femoral arteries in a controlled rate freezer, using an aluminum probe, both in the presence at (-80 degrees C to 1 degrees C/min) and absence (at -20 degrees C for 2 or 5 mins) of CPA and Fetal bovine serum (FBS). Following freezing, artery samples were subjected to uniaxial tensile testing. The weights of the tissue were measured before and after freezing. Our results suggest that freezing does have an effect on stress-strain properties, particularly in the low stress region corresponding to physiological conditions. The mechanisms of this change in mechanical properties may include the loss of smooth muscle cell viability, damage to...Continue Reading

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Citations

Sep 11, 2007·Annals of Biomedical Engineering·Jorge L Jimenez RiosYoed Rabin
Oct 19, 2007·Annals of Biomedical Engineering·Saravana Kumar BalasubramanianJohn C Bischof
Jan 29, 2010·Annals of Biomedical Engineering·Ramji T VenkatasubramanianJohn C Bischof
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