Effects of frequency of exposure to iron-sucrose on the incidence of dental caries in desalivated rats

Caries Research
J C MiguelS K Pearson

Abstract

World Health Organization (WHO) estimates that 2.5 billion people have anemia caused by iron deficiency that could be prevented by fortification of food; sugar, for example, has been used successfully as a vehicle for dietary iron fortification. The inclusion of 88 ppm of iron (as FeSO4) co-crystallized with sugar has been shown to reduce the incidence of caries by more than 30% when rats are fed 17 meals daily at hourly intervals. The purpose of the present study was to determine the influence of varying the number of daily exposures to iron on caries in desalivated rats. Four litters of 12 Sprague-Dawley rats were desalivated when aged 25 days and caged in a programmed feeder. All animals received their essential nutrition by gavage and 17 meals of sucrose daily. In Group A, 6 meals contained 88 ppm Fe; in Group B, 3 meals continued iron: Group C had 2 meals, and in Group D, no iron was added. The investigation continued for 3 weeks. Smooth-surface and sulcal (in parentheses) caries scores were: Group A 60.8 (39.4); Group B 72.4 (41.3); Group C 73.1 (41.3), and Group D 92.9 (49.2). Caries scores in all the iron groups were statistically lower than in the control group. Severity scores followed a similar pattern. Thus, as few ...Continue Reading

Citations

May 1, 1997·Archives of Oral Biology·J C MiguelS K Pearson
Jun 21, 2011·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Koji WatanabeKenshi Maki
Jun 20, 2006·Archives of Oral Biology·Marília Afonso Rabelo BuzalafAna Carolina Magalhães
Nov 26, 2005·Archives of Oral Biology·Cleide Cristina Rodrigues MartinhonMarília Afonso Rabelo Buzalaf
May 11, 2011·Archives of Oral Biology·Karina Mirela Ribeiro Pinto AlvesAlberto Carlos Botazzo Delbem
Jul 21, 2012·Caries Research·A C B DelbemJ C S Moraes
Feb 1, 2007·Journal of Applied Oral Science : Revista FOB·Melissa Thiemi KatoMarília Afonso Rabelo Buzalaf
Aug 8, 2019·Caries Research·Vanessa Silva de RezendeRaquel Gonçalves Vieira-Andrade

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