PMID: 6992177Jan 1, 1980Paper

Effects of frusemide on plasma concentrations of renin and prostaglandins E and A in fetal sheep

Prostaglandins and Medicine
J M Moutquin, G C Liggins

Abstract

The role of the renin-angiotensin system and prostaglandins in the regulation of fetal vascular homeostasis was investigated by measuring hemodynamic and hormonal responses to fetal administration of frusemide in ten intact and five bilaterally nephrectomised fetal lambs. The increase in fetal arterial pH and the fall in pCO2 following treatment with frusemide suggests that this drug may influence placental exchange of blood gases. The increase in plasma renin activity without accompanying changes in plasma PGE does not support a direct relationship between renin release and renal prostaglandin E production in the fetal lamb.

References

Jul 1, 1977·The Journal of Clinical Endocrinology and Metabolism·S Y Tan, P J Mulrow
May 1, 1971·Acta Endocrinologica·M D NielsenJ Giese
Jan 1, 1972·The Journal of Physiology·G S DawesR T Richards
Jun 1, 1974·Pediatric Research·F G SmithR A Bashore
Aug 29, 1974·The New England Journal of Medicine·S Oparil, E Haber
Jan 10, 1974·Prostaglandins·A AttallahE Brazelton
Jan 1, 1966·Canadian Journal of Physiology and Pharmacology·P A Morrin
May 1, 1964·The Journal of Physiology·S CASSINL B STRANG
Feb 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·L B BERMAN, A EBRAHIMI

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Citations

Jun 1, 1995·International Journal of Behavioral Development·B LozoffA W Wolf
Jan 22, 1998·The American Journal of Physiology·M Z ZhangJ A McKanna
Jan 1, 1982·Clinical and Experimental Hypertension. Part B, Hypertension in Pregnancy·J M Moutquin, N Leblanc
Nov 1, 1981·Kidney International·J R MatsonJ E Robillard

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