Effects of fucoxanthin on autophagy and apoptosis in SGC-7901cells and the mechanism.

Journal of Cellular Biochemistry
Yue ZhuXiamin Hu

Abstract

Autophagy and apoptosis are involved in the development of a variety of cancers. Fucoxanthin is a natural compound known to have antitumor effects, so we aimed to explore its effects on autophagy and apoptosis in gastric cancer SGC7901 cells. Specifically, we performed methyl thiazolyl tetrazolium assay, transmission electron microscopy, real-time polymerase chain reaction, Western blot analysis, immunofluorescence assay, and cell apoptosis analysis to clarify the role of fucoxanthin in SGC-7901 cells. Our results indicate that fucoxanthin significantly inhibits the viability of SGC-7901 cells, effectively inducing both autophagy and apoptosis by up-regulating the expressions of beclin-1, LC3, and cleaved caspase-3 (CC3), and by down regulating Bcl-2. Fucoxanthin-induced autophagy also seems to occur before, and may promote apoptosis.

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Citations

Jan 10, 2019·Marine Drugs·Giuseppe ErcolanoAngela Ianaro
Oct 31, 2018·Marine Drugs·Djenisa H A RochaDiana C G A Pinto
Aug 30, 2020·Cancers·Lenka KoklesovaPeter Kubatka
Dec 10, 2020·International Journal of Molecular Sciences·Sarah MéresseBenoît Chénais
Nov 22, 2020·Marine Drugs·Lei CaoHyeung-Rak Kim
Dec 17, 2020·Marine Drugs·Han XiaoShuliang Song
Jan 14, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Minkyung BaeJi-Young Lee
Jul 11, 2021·Neurochemistry International·Ashish KumarRenu Wadhwa

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