Effects of fullerene guests on the stability of 1-palmitoyl-2-oleoylphosphatidylcholine liposomes

Soft Matter
Paolo De MariaDiana Velluto

Abstract

Membrane stability of extruded large unilamellar vesicles () formed by 1-palmitoyl-2-oleoylphosphatidylcholine () containing fullerene C or an amphiphilic fullerene derivative, 2-[2-(2-fulleropyrrolidin-1-ylethoxy)-ethoxy]-ethanol (), has been investigated by spectrofluorimetrically monitoring the spontaneous release of entrapped carboxyfluorescein (). Under controlled conditions of temperature, osmolarity and pH, these guests increase the stability of the liposomal membrane as shown by the decrease in the rate of outflux of . The stability conferred to the liposomes by C and has been compared with that conferred by the well-known stabilizing guest 1,2-dipalmitoyl--glycero-3-phosphoethanolamine--[methoxy-(polyethylene glycol)-2000] ammonium salt (). The addition of amphiphilic molecules, such as non-ionic surfactants, which intercalate into the membrane bilayer, and of sucrose or NaCl, which induce a hyposmotic stress, has been extensively investigated in order to get information on how to modulate the release of entrapped . This information could hopefully be useful in the formulation of new drug delivery systems as well as for getting a deeper understanding of the mechanisms of the formation/enclosure of channels through the ...Continue Reading

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Citations

Sep 20, 2008·Chemical Communications : Chem Comm·Illa RamakanthArchita Patnaik
Oct 12, 2010·Organic & Biomolecular Chemistry·Antonella FontanaDomenico Spinelli
Apr 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Romina ZappacostaAntonella Fontana
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Sep 6, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Marco BortolusAlberta Ferrarini

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