Effects of fumonisin B1 in pregnant rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
T F CollinsJ I Rorie

Abstract

Fumonisin B1 (FB1), the major mycotoxin from Fusarium moniliforme, has been implicated as a causative agent in several animal and human diseases. Despite animal toxicity studies and human epidemiological studies of FB1, knowledge of its reproductive effects is scarce. In this study, one of a series of proposed studies that will allow extrapolation to humans, pregnant rats were given oral doses of 0, 1.875, 3.75, 7.5 or 15 mg FB1/kg on gestation days 3 16. Caesarean sections were performed on day 17 or 20, and maternal condition, implantation efficiency, foetal viability and foetal development were measured. Dose-related decreases in overall feed consumption and body weight gain were seen, but only the feed consumption decrease at 15 mg/kg, and the decreased body weight gain at 15 mg/kg on days 0-17 were statistically significant. Foetal body weights at day 17 were similar in control and treated groups; but in day-20 foetuses, female weight and crown-rump length were significantly decreased at 15 mg/kg. FB1 was not teratogenic at the doses tested, and no dose-related effects were seen in either skeletal or soft-tissue development. In day-17 animals, maternal and foetal brain, liver and kidney tissues, and maternal serum were pre...Continue Reading

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Citations

Mar 1, 2006·Mycotoxin Research·K A VossR T Riley
Sep 12, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T F CollinsJ I Rorie
May 22, 2001·Environmental Health Perspectives·K A VossJ K Porter
Jun 4, 2010·Molecular Nutrition & Food Research·Martin E KimanyaPatrick Kolsteren
Aug 6, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Thomas F X CollinsDennis I Ruggles
Jun 17, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Janee Gelineau-van WaesRonald T Riley
Mar 30, 2018·Toxicology and Industrial Health·Bence SomoskőiSándor Cseh

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