PMID: 8581573Oct 1, 1995Paper

Effects of function and weight-bearing on the healing of full-thickness cartilage defects in rats

Scandinavian Journal of Medicine & Science in Sports
O Grundnes, O Reikerås

Abstract

The effects of different degrees of active motion were studied in 30 male Wistar rats. In all rats a full-thickness cartilage defect of 1.0 mm in diameter was made in the medial condyle of both femurs. The rats were then allocated to the following three groups; i) exercising group which followed a 4-week training program of moderate intensity, ii) a non-weight-bearing group in which unilateral achilles tenotomy was made to reduce weight-bearing and iii) control rats which were allowed normal cage activity. Healing of the defect was evaluated by planimetric analysis and histologic evaluation. Effects of the training program was confirmed by a lesser weight increase in the exercise group. Planimetric analysis revealed no differences between the groups in the area of the original defect at the end of the experiment. There were no differences in healing ratio (area of healing/area of original defect) between the exercise and control groups, whereas the healing ratio was increased in the non-weight-bearing limbs compared with control and exercised rats. The favorable effect of non-weight-bearing was further indicated by differences in healing ratio between the two limbs in the non-weight-bearing group. Histological evaluation showed...Continue Reading

References

Feb 1, 1992·Acta Orthopaedica Scandinavica·O Grundnes, O Reikerås
Apr 1, 1991·Acta Orthopaedica Scandinavica·O Grundnes, O Reikerås
Dec 12, 1974·The New England Journal of Medicine·H J Mankin
Jul 1, 1972·Clinical Orthopaedics and Related Research·J A Fuller, F N Ghadially
Feb 1, 1983·Acta Orthopaedica Scandinavica·E Tøndevold, J Bülow
Feb 1, 1980·The Anatomical Record·A Vignery, R Baron

❮ Previous
Next ❯

Citations

Feb 14, 2009·Journal of Bone and Mineral Metabolism·Yoshihisa AnrakuYuji Hiraki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.