Effects of functional electrical stimulation on gait function and quality of life for people with multiple sclerosis taking dalfampridine

International Journal of MS Care
Lori MayerEdward J Fox

Abstract

Multiple sclerosis (MS) can adversely affect gait, causing gait slowing, loss of balance, decreased functional mobility, and gait deficits, such as footdrop. Current treatments for gait dysfunction due to MS are pharmacologic, using dalfampridine, or orthotic, using an ankle-foot orthosis. Functional electrical stimulation (FES) to the fibular nerve stimulates active dorsiflexion and provides an alternative treatment for gait dysfunction caused by footdrop. The objective of this study was to determine the effect of FES on gait function and the impact of MS on walking and quality of life for people with MS taking a stable dalfampridine dose. Participants demonstrating gait slowing and footdrop completed the Timed 25-Foot Walk (T25FW) test, 6-Minute Walk (6MW) test, GaitRite Functional Ambulation Profile, 12-item Multiple Sclerosis Walking Scale (MSWS-12), and 36-item Short Form Health Status Survey (SF-36) at screening without FES; the measures were repeated with FES at baseline, 1 month, and 3 months. Twenty participants (8 men and 12 women) completed this unblinded case series study. The mean age, duration of MS, and time taking dalfampridine were 51.7, 15.8, and 1.4 years, respectively. Changes from screening to baseline and ...Continue Reading

References

Jun 1, 1995·Stroke; a Journal of Cerebral Circulation·J PerryS J Mulroy
Oct 12, 1999·Multiple Sclerosis : Clinical and Laboratory Research·L D JacobsD H Snyder
Dec 22, 1999·Archives of Physical Medicine and Rehabilitation·P N TaylorI D Swain
Aug 17, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·J H Burridge, D L McLellan
Aug 30, 2000·Multiple Sclerosis : Clinical and Laboratory Research·M KaufmanJ Norton
Dec 21, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·A-K IsakssonL-G Gunnarsson
Aug 4, 2006·Neurorehabilitation and Neural Repair·Richard B SteinKouji Ihashi
Nov 8, 2006·Multiple Sclerosis : Clinical and Laboratory Research·C L MartinM P Galea
Oct 19, 2007·Multiple Sclerosis : Clinical and Laboratory Research·Myla D GoldmanJeffrey A Cohen
Dec 26, 2007·American Journal of Physical Medicine & Rehabilitation·Jeffrey M Hausdorff, Haim Ring
Jun 25, 2008·Multiple Sclerosis : Clinical and Laboratory Research·L PaulA McFadyen
Aug 2, 2008·Neurology·A D GoodmanUNKNOWN Fampridine MS-F202 Study Group
Dec 27, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Haim RingJeffrey M Hausdorff
Oct 29, 2009·Neurorehabilitation and Neural Repair·Dirk G EveraertRichard B Stein
Nov 18, 2009·Current Medical Research and Opinion·Matthew H Sutliff
Mar 10, 2010·Disability and Rehabilitation·Sukanta K SabutManjunatha Mahadevappa
Mar 17, 2010·Gait & Posture·Robert W MotlMyla Goldman
Jun 23, 2011·Therapeutic Advances in Neurological Disorders·Andrew R Blight
Jun 29, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Bernd C Kieseier, Carlo Pozzilli
Nov 28, 2012·Patient Related Outcome Measures·Kamila RasovaMichaela Sedova
Mar 28, 2013·Multiple Sclerosis International·Michael J Socie, Jacob J Sosnoff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.