Effects of functional polymorphisms related to catecholaminergic systems on changes in blood catecholamine and cardiovascular measures after alcohol ingestion in the Japanese population

Alcoholism, Clinical and Experimental Research
Fusae T NishimuraKiyofumi Saijoh

Abstract

The polymorphism of human aldehyde dehyrogenase-2 (ALDH2) Glu(487)Lys is well known to be a crucial factor underlying the genetic background for alcohol sensitivity in Asian populations. Subjects with the inactive Lys(487) allele show a marked increase in blood acetaldehyde level after alcohol intake, which results in facial flushing and various cardiovascular-related symptoms. However, other polymorphisms related to catecholaminergic systems that tightly regulate the activity of the sympathetic nervous system may also influence the physiological changes after acute alcohol intake. We investigated whether, together with the ALDH2 Gly(487)Lys and ADH1B Arg(47)His genotype, putative functionally important polymorphisms, including 9 loci in 7 human genes, were associated with changes in blood catecholamine levels and cardiovascular measures after alcohol ingestion. Forty-nine young Japanese males were subjected to blood catecholamine analysis after alcohol ingestion. Among them, 28 were also subjected to heart rate variability and blood pressure analysis. The contribution of polymorphisms to the alcohol-induced response was analyzed by multiple regression analysis. Among the polymorphisms examined in this study, haplotypes of the ...Continue Reading

References

Nov 1, 1978·European Journal of Pharmacology·B M AlturaB T Altura
Jan 15, 1991·The American Journal of Cardiology·J HayanoK Takata
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L C HsuA Yoshida
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·Y MizoiI Ijiri
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A YoshidaM Ikawa
Nov 5, 1997·Alcoholism, Clinical and Experimental Research·Y C ShenG Y Xia
Nov 3, 1998·Human Genetics·S Z SabolD Hamer
Nov 5, 1998·Alcoholism, Clinical and Experimental Research·J B WhitfieldN G Martin
Apr 23, 1999·The Journal of Biological Chemistry·D A MasonS B Liggett
Feb 24, 2001·Alcoholism, Clinical and Experimental Research·T K LiV A Ramchandani
May 30, 2001·American Journal of Medical Genetics·M B MannD E Comings
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·C J ErikssonJ B Whitfield
Dec 12, 2001·The Journal of Clinical Endocrinology and Metabolism·C CavadasE Grouzmann
Feb 21, 2002·American Journal of Human Genetics·Koustubh RanadeNeil Risch
Apr 18, 2002·Journal of Neuroimmunology·Michael B MannDavid E Comings
Dec 21, 2002·Autonomic Neuroscience : Basic & Clinical·Fusae T NishimuraHisao Nishijo
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Naoko SuzukiKoichiro Yasuda
Nov 10, 2005·Journal of Neurochemistry·Yuan JiRichard M Weinshilboum
Jun 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Cláudia CavadasEric Grouzmann
Jul 25, 2006·Trends in Endocrinology and Metabolism : TEM·Koichiro YasudaKinsuke Tsuda
Sep 26, 2007·American Heart Journal·Tetsuro MatsunagaKinsuke Tsuda

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