Effects of Fuzheng Paidu tablet on peripheral blood T lymphocytes, intestinal mucosa T lymphocytes, and immune organs in cyclophosphamide-induced immunosuppressed mice

Human Vaccines & Immunotherapeutics
Mingsan MiaoJingjing Shi

Abstract

The aim of this study is to investigate the effects of a Fuzheng Paidu tablet on peripheral blood T lymphocytes, intestinal mucosa T lymphocytes, and immune organs in cyclophosphamide (CY)-induced immunosuppressed mice. The experimental mice (but not the control mice) were intraperitoneally injected with 80 mg/kg of CY solution every day for 3 consecutive days. Meanwhile, each mouse was administered with corresponding drugs for 7 continuous days. Then, 1 h after the last administration, each index was detected. The Fuzheng Paidu tablet significantly increases the CD4+/CD8+ ratio (P < 0.01) and the number of CD3+ and CD4+ cells in immunosuppressed mice (P < 0.01). In addition, the tablet apparently enhances the CD3+, CD4+, and CD8+ levels in the intestinal mucosal immune system (P < 0.01) as well as reverses the reduction of spleen lymphoid nodules and lymphocytes (P < 0.01). It also significantly improves intestinal inflammation, thymic atrophy, and sparse thymocytes in immunosuppressed mice (P < 0.01). The Fuzheng Paidu tablet greatly increases the levels of peripheral blood T lymphocytes and intestinal mucosal T lymphocytes as well as impoves atrophied thymuses and spleens in CY-induced immunosuppressed mice.

References

Feb 11, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M I LusterG J Rosenthal
Jan 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M I LusterJ H Dean
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B PeláezJ L Subiza

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BETA
gene knockout etc
flow cytometry

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