PMID: 2484728Oct 23, 1989Paper

Effects of GABA and L-glutamic acid on the potassium-evoked in vitro release of substance P- and neurokinin A-like immunoreactivities are different in the rat striatum and substantia nigra

Neuroscience Letters
C Humpel, A Saria

Abstract

Slices of the rat substantia nigra and striatum were superfused in vitro to measure release of tachykinins (TKs). Potassium (30 and 60 mM) infusion caused a 3- to 10-fold outflow of both substance P-like immunoreactivity (SP-LI) and neurokinin A-like immunoreactivity (NKA-LI) in the substantia nigra as well as in the striatum as measured by radioimmunoassay. The potassium-evoked release of SP-LI and NKA-LI was significantly, but not completely (by 25-70%) inhibited by simultaneous perfusion with L-glutamic acid (50 microM) and gamma-aminobutyric acid (GABA, 50 microM) in the substantia nigra. No significant inhibition was, however, observed in the striatum. The present data indicate a differential regulation of tachykinins in the striatum and substantia nigra by L-glutamic acid and GABA. The presynaptic regulation of TK release may therefore differ in the dendritic and terminal region of the striatonigral pathway.

References

Aug 11, 1978·Brain Research·T M Jessell
Sep 21, 1978·Nature·T A James, M S Starr
Jan 1, 1986·Experimental Brain Research·M Herrera-MarschitzU Ungerstedt
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J E KrauseA D Hershey
Jan 1, 1988·Annual Review of Neuroscience·J E Maggio
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H KotaniS Nakanishi

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