PMID: 1704674Dec 1, 1990Paper

Effects of galanin and calcitonin gene-related peptide on insulin and glucagon secretion in man

Acta Endocrinologica
B Ahrén

Abstract

To study the influence of the pancreatic neuropeptides, galanin and calcitonin gene-related peptide, on insulin and glucagon secretion in man, synthetic porcine galanin (80 pmol.kg-1.min-1; N = 6) or synthetic human calcitonin gen-related peptide (10 pmol.kg-1.min-1; N = 5) was infused intravenously in human volunteers. Following 5 min of infusion, arginine (5 g bolus + 10 mg.kg-1.min-1) was given. Galanin did not affect basal or arginine-stimulated insulin secretion judged from determinations of plasma insulin and C-peptide. Similarly, galanin did not affect arginine-stimulated glucagon secretion. Calcitonin gene-related peptide did not affect basal or arginine-stimulated insulin or glucagon secretion. However, calcitonin gene-related peptide slightly potentiated the arginine-induced hyperglycemia (p less than 0.01). Thus, in man, galanin has no influence on insulin or glucagon secretion when infused at 80 pmol.kg-1.min-1, whereas CGRP at 10 pmol.kg-1.min-1 induces slight hyperglycemia.

Citations

Jul 1, 1992·Diabetes/metabolism Reviews·W Creutzfeldt, M Nauck
May 1, 1991·Cell and Tissue Research·S LindskogF Sundler
Jul 1, 1993·Diabetologia·J J HolstH Kofod
Aug 8, 2001·Journal of Neuroendocrinology·E Adeghate, A S Ponery
Oct 1, 1991·Acta Physiologica Scandinavica·B E DunningB Ahrén
Oct 1, 1993·Acta Physiologica Scandinavica·B E Dunning, B Ahrén
Oct 1, 1991·Journal of Endocrinological Investigation·M E VrontakisH G Friesen
Jun 30, 1992·Annals of the New York Academy of Sciences·D Bretherton-WattS R Bloom
Oct 27, 2015·Histochemistry and Cell Biology·P PodlaszJ Kaleczyc
Aug 6, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·E PaschettaG Musso
May 25, 1999·Metabolism: Clinical and Experimental·M C MooreA D Cherrington

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