PMID: 1704674Dec 1, 1990Paper

Effects of galanin and calcitonin gene-related peptide on insulin and glucagon secretion in man

Acta Endocrinologica
B Ahrén


To study the influence of the pancreatic neuropeptides, galanin and calcitonin gene-related peptide, on insulin and glucagon secretion in man, synthetic porcine galanin (80; N = 6) or synthetic human calcitonin gen-related peptide (10; N = 5) was infused intravenously in human volunteers. Following 5 min of infusion, arginine (5 g bolus + 10 was given. Galanin did not affect basal or arginine-stimulated insulin secretion judged from determinations of plasma insulin and C-peptide. Similarly, galanin did not affect arginine-stimulated glucagon secretion. Calcitonin gene-related peptide did not affect basal or arginine-stimulated insulin or glucagon secretion. However, calcitonin gene-related peptide slightly potentiated the arginine-induced hyperglycemia (p less than 0.01). Thus, in man, galanin has no influence on insulin or glucagon secretion when infused at 80, whereas CGRP at 10 induces slight hyperglycemia.


Jul 1, 1992·Diabetes/metabolism Reviews·W Creutzfeldt, M Nauck
May 1, 1991·Cell and Tissue Research·S LindskogF Sundler
Jul 1, 1993·Diabetologia·J J HolstH Kofod
Aug 8, 2001·Journal of Neuroendocrinology·E Adeghate, A S Ponery
Oct 1, 1991·Acta Physiologica Scandinavica·B E DunningB Ahrén
Oct 1, 1993·Acta Physiologica Scandinavica·B E Dunning, B Ahrén
Oct 1, 1991·Journal of Endocrinological Investigation·M E VrontakisH G Friesen
Jun 30, 1992·Annals of the New York Academy of Sciences·D Bretherton-WattS R Bloom
Oct 27, 2015·Histochemistry and Cell Biology·P PodlaszJ Kaleczyc
Aug 6, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·E PaschettaG Musso
May 25, 1999·Metabolism: Clinical and Experimental·M C MooreA D Cherrington

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