Effects of galanin subchronic treatment on memory and muscarinic receptors

Neuroscience
G Barreda-GómezR Rodríguez-Puertas

Abstract

The cholinergic pathways, which originate in the basal forebrain and are responsible for the control of different cognitive processes including learning and memory, are also regulated by some neuropeptides. One of these neuropeptides, galanin (GAL), is involved in both neurotrophic and neuroprotective actions. The present study has evaluated in rats the effects on cognition induced by a subchronic treatment with GAL by analyzing the passive avoidance response, and the modulation of muscarinic cholinergic receptor densities and activities. [(3)H]-N-methyl-scopolamine, [(3)H]-oxotremorine, and [(3)H]-pirenzepine were used to quantify the density of muscarinic receptors (MRs) and the stimulation of the binding of guanosine 5'-(γ-[(35)S]thio)triphosphate by the muscarinic agonist, carbachol, to determine their functionality. Some cognitive deficits that were induced by the administration of artificial cerebrospinal fluid (aCSF) (i.c.v. aCSF 2 μl/min, once a day for 6 days) were not observed in the animals also treated with GAL (i.c.v. 1.5 mmol in aCSF, 2 μl/min, once a day for 6 days). GAL modulates the changes in M1 and M2 MR densities observed in the rats treated with aCSF, and also increased their activity mediated by G(i/o) pro...Continue Reading

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Citations

Aug 9, 2016·Brain Structure & Function·Joanne C DamborskyJerrel L Yakel
Jan 28, 2017·Anatomy & Cell Biology·Juhyun Song, Oh Yoen Kim
Nov 20, 2016·Neural Regeneration Research·Xiao-Feng XuWei Qiu
Jun 6, 2018·Journal of Alzheimer's Disease : JAD·Alberto Llorente-OvejeroRafael Rodríguez-Puertas
Aug 10, 2018·European Journal of Pharmacology·Joshua A BurkEden B Maness
May 27, 2021·ACS Chemical Neuroscience·Alberto Llorente-OvejeroRafael Rodríguez-Puertas

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