Effects of garlic supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials

Phytotherapy Research : PTR
Asieh PanjeshahinMahdieh Hosseinzadeh

Abstract

Current evidence on the beneficial effects of garlic on liver enzymes is contradictory. Therefore, the aim of this systematic review and meta-analysis is to evaluate the effect of garlic supplementation on human liver enzymes, such as Alanine Transaminase (ALT/SGPT) and Aspartate Transaminase (AST/SGOT). To collect the required data, PubMed, Scopus, ISI Web of Science, and Google scholar databases were systematically searched from inception to June 2019. A meta-analysis was conducted using the random-effects model to evaluate the effects of garlic supplementation on ALT and AST levels. The Cochran's Q-test and inconsistency index were also used to evaluate heterogeneity among the studies. Among a total of 15,514 identified articles, six studies (containing 301 participants) met the inclusion criteria. Results of the meta-analysis showed that garlic supplementation significantly decreased AST level (Hedges' g = -0.36, 95% confidence interval [CI]: -0.72, -0.004, p = .047); whereas, it had no significant effect on ALT level (Hedges' g = -0.22, 95% CI: -0.64, 0.20, p = .310). Results showed that garlic supplementation reduced AST levels significantly; however, had no significant effect on ALT levels. Further studies are still need...Continue Reading

References

Sep 15, 1989·Annals of Internal Medicine·M M Van Ness, A M Diehl
Jan 17, 1981·Lancet·T ArigaT Tamada
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Aug 1, 1997·Biochemical Society Transactions·R T KasinathD J Maslin
Jul 31, 1998·Archives of Physical Medicine and Rehabilitation·J M MeythalerM Rosner
Jul 28, 1999·Seminars in Liver Disease·C J McClainD Hill
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P AnguloK D Lindor
Apr 12, 2001·Seminars in Liver Disease·Y Falck-YtterA J McCullough
Feb 26, 2003·Phytotherapy Research : PTR·S K BanerjeeS K Maulik
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
Dec 9, 2008·Journal of Atherosclerosis and Thrombosis·Igor A SobeninAlexander N Orekhov
May 19, 2009·Archives of Toxicology·Arthur I CederbaumDefeng Wu
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Apr 20, 2010·Journal of Hepatology·Sylvie NaveauGabriel Perlemuter
Jun 30, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Juan C Bournat, Chester W Brown
Jun 15, 2011·Journal of Medicinal Food·Min Hee KimMee Ree Kim
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Dec 6, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tao ZengKe-Qin Xie
Oct 17, 2012·Journal of Agricultural and Food Chemistry·Rajasekaran RaghuLee-Yan Sheen
Feb 20, 2013·Journal of Hepatology·Martin BlachierFrançoise Roudot-Thoraval
Mar 6, 2013·Nature Reviews. Gastroenterology & Hepatology·Geoffrey C FarrellShiv Chitturi
Apr 18, 2013·Nutrition Reviews·Karin RiedPeter Fakler
Jun 12, 2013·The American Journal of Gastroenterology·Tania M WelzelKatherine A McGlynn
Jun 1, 2011·Nutrition Research Reviews·S V RanaR P Ola
Jan 6, 2015·The Journal of Clinical Hypertension·Hai-Peng WangXiang-Jun Yang
May 12, 2015·Journal of Immunology Research·Rodrigo ArreolaDaniel Ortuño-Sahagún
Nov 3, 2015·Drug Discovery Today·Paolo FagoneFerdinando Nicoletti
Nov 6, 2015·International Journal of Molecular Sciences·Sha LiYibin Feng
Dec 15, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Lukas SchwingshacklGeorg Hoffmann
Apr 6, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lian-Yun ChenShi-Zhong Zheng
Dec 7, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Min-Jie GuanTao Zeng

❮ Previous
Next ❯

Citations

Jun 21, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Marcia RibeiroDenise Mafra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of AOAC International
Elias E Mazokopakis
Manufacturing Chemist and Aerosol News
J RAE
Molecular Nutrition & Food Research
Edzard Ernst
BMJ : British Medical Journal
P Mansell, J P Reckless
© 2021 Meta ULC. All rights reserved