PMID: 6408603Apr 1, 1983Paper

Effects of gas density on pulmonary gas exchange of normal man at rest and during exercise

Pflügers Archiv : European journal of physiology
B NemeryA Frans

Abstract

Changes in the physical properties of inspired gas might be expected to influence the distribution of ventilation in the lungs as well as the diffusive and convective (cardiogenic) mixing of inspired gas with lung residual gas, thus possibly affecting pulmonary gas exchange for O2 and CO2. The purpose of our work was to assess to what extent this occurs in practise in human subjects, who could compensate for the changes directly brought about by altering the physical characteristics of the inhaled gas by changing their breathing pattern. Six healthy, non-smoking men breathed, at rest and during moderate exercise, gas mixtures containing 21% oxygen completed either by 79% nitrogen (air), helium (O2-He) or sulphur hexafluoride (O2-SF6). We observed that the inhalation of these three different gas mixtures whilst at rest did not affect arterial partial pressures of O2 or CO2, the physiological dead space to tidal volume ratio, or the alveolo-aADCO2). During exercise, AaDO2 was slightly (2-3 mm Hg) but significantly higher with both O2-He and O2-SF6 than with air. Although minute ventilation did not change, breathing frequency was slightly but significantly affected by the type of gas mixture breathed, being lower with O2-SF6 and h...Continue Reading

References

Aug 1, 1976·Journal of Applied Physiology·L D WoodH Levison
Oct 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·N GledhillA C Bryan
Jul 1, 1972·Journal of Applied Physiology·R R MartinN R Anthonisen
Jan 1, 1970·Pflügers Archiv : European journal of physiology·W LieseJ P Pichotka
Apr 1, 1971·Journal of Applied Physiology·H A SaltzmanJ A Kylstra
Aug 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·H D Van LiewD K Sponholtz
Jan 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·W Nixon, A Pack

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Citations

Jun 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P ZhangI Yoshiya
Jun 5, 2002·American Journal of Respiratory and Critical Care Medicine·Brian L GrahamDavid J Cotton
Sep 21, 2010·European Journal of Applied Physiology·Pierantonio LavenezianaPaolo Palange
Aug 17, 2001·International Anesthesiology Clinics·Y Fujii
Jul 1, 1997·Journal of Applied Physiology·B S KrishnanC G Gallagher

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