Effects of gatifloxacin on phagocytosis, intracellular killing and oxidant radical production by human polymorphonuclear neutrophils

International Journal of Antimicrobial Agents
P C BragaE Fonti

Abstract

The ingestion and killing of bacteria by phagocytic cells is an important step in the sequence of interactions between invading microorganisms and host defense systems and may be affected by antibiotics. We investigated the effects of gatifloxacin on the phagocytosis, killing and oxidative bursts of human polymorphonuclear neutrophils (PMNs). The percentage phagocytosis and the phagocytosis index were unaffected by exposure of Escherichia coli strains to sub-MICs of gatifloxacin to a 1/64 dilution. However a significant increase in percentage intraphagocytic killing and the killing index occurred in one E. coli strain at 1/32 MIC and in two strains at 1/16 MIC. The incubation of PMNs with sub-MICs and supra-MICs of gatifloxacin (to 32 MIC) did not affect the oxidative bursts.

References

Sep 1, 1991·Antimicrobial Agents and Chemotherapy·I Odenholt-TornqvistO Cars
May 12, 1989·Journal of Immunological Methods·R Bellinati-PiresM M Carneiro-Sampaio
Dec 1, 1985·European Journal of Clinical Microbiology·A Forsgren, P I Bergkvist
Jan 1, 1985·The Journal of Antimicrobial Chemotherapy·H Sous, I Hirsch
Apr 1, 1982·European Journal of Clinical Microbiology·D Milatović
Dec 1, 1994·The Journal of Antimicrobial Chemotherapy·J PemánM Gobernado
May 1, 1993·Diagnostic Microbiology and Infectious Disease·S A Sonstein, J C Burnham
Jul 1, 1993·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C KönigJ Blaser
Dec 1, 1995·Antimicrobial Agents and Chemotherapy·M NakashimaH Uchida

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Citations

Oct 2, 2003·The Annals of Pharmacotherapy·Guy W AmsdenJoseph S Bertino

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