Effects of gender affirming hormone therapy on body mass index in transgender individuals: A longitudinal cohort study

Journal of Clinical & Translational Endocrinology
Pichatorn SuppakitjanusantVin Tangpricha

Abstract

Many transgender people take hormone therapy to affirm their gender identity. One potential long-term consequence of gender affirming hormone therapy is increased body mass index (BMI), which may be associated with metabolic syndrome, cardiovascular disease and higher mortality. Only a few published studies explored changes in BMI in transgender people taking gender affirming hormone therapy (GAHT). To examine the changes in BMI longitudinally in response to GAHT in transgender women and men. We conducted a retrospective cohort study of transgender individuals who received GAHT from the endocrinology clinic between January 1, 2000 and September 6, 2018. Subjects who sought GAHT were included if they had two separate measurements of BMI and were excluded if they had a BMI greater than 35 kg/m2 or were missing demographic data at entry. We used a linear mixed model to analyze the longitudinal change in BMI. There were a total of 227 subjects included in this cohort. Among subjects already on GAHT, transgender women were receiving GAHT longer than transgender men (6.59 ± 9.35 vs 3.67 ± 3.43 years, p-value = 0.04). Over the period of 7 years, there was a significant increase in BMI in transwomen who newly initiated GAHT (p-value 0....Continue Reading

Citations

Aug 18, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M KyinnM S Irwig

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