Effects of gender, body weight, and blood glucose dynamics on the growth hormone response to the glucagon stimulation test in patients with pituitary disease

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
Jessica R WilsonJessica K Devin

Abstract

Body weight blunts the growth hormone (GH) response to provocative stimuli. The appropriate GH cut-off to confirm GH deficiency in obese and overweight patients undergoing the glucagon stimulation test (GST) has recently been questioned. We hypothesized that the peak GH would be inversely related to the nadir blood glucose (BG) after glucagon and that this may be a mechanism influencing peak GH in overweight patients. This retrospective study examined effects of gender, body weight, and BG dynamics on GH response to GST in patients evaluated in our Pituitary Center. Adult patients who underwent GST from September 2009-2014 were included. Continuous variable comparisons were analyzed using the Mann-Whitney U-test and categorical data by Fisher's Exact Test. Spearman correlation was used to determine associations between continuous variables. 42 patients (N=28, 66.7% female) had sufficient data for analysis. Obese patients (N=26) had a reduced GH response, summarized as GH area under the curve (AUC) (p=0.03 vs. non-obese patients) and higher BG during GST, summarized as AUC (p<0.01 vs. non-obese patients). Obese women (N=19), in particular, stimulated lower (p=0.03 vs. non-obese women) and had a higher nadir BG (p=0.03 vs. non-ob...Continue Reading

References

Jan 1, 1991·The Journal of Clinical Endocrinology and Metabolism·J D VeldhuisG Lizarralde
May 1, 1990·The Journal of Clinical Endocrinology and Metabolism·F BarbettiG Tamburrano
Mar 1, 1994·The Journal of Clinical Endocrinology and Metabolism·S J HolmesS M Shalet
Apr 10, 2002·Clinical Endocrinology·José Manuel GómezAnna Sanmartí
Mar 11, 2004·Journal of Endocrinological Investigation·F L ConceiçãoM Vaisman
Oct 7, 2004·Endocrine Reviews·Kin-Chuen LeungKen K Y Ho
Aug 3, 2005·European Journal of Endocrinology·Ginevra CorneliGianluca Aimaretti
Aug 11, 2005·The Journal of Clinical Endocrinology and Metabolism·P M MahR J M Ross
May 10, 2007·The Journal of Clinical Endocrinology and Metabolism·Georg BrabantAndy Toogood
Jul 5, 2007·European Journal of Endocrinology·Kirstine StochholmAnders Green
Dec 15, 2007·Metabolism: Clinical and Experimental·Maria Claudia Peixoto CenciMario Vaisman
Aug 6, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Fernando M A GiuffridaJosé Gilberto H Vieira
Sep 5, 2008·Annals of Clinical Biochemistry·Julian H Barth, Paul E C Sibley
May 28, 2009·The Journal of Clinical Endocrinology and Metabolism·J FrystykK K Miller
May 24, 2011·The Journal of Clinical Endocrinology and Metabolism·Mark E MolitchUNKNOWN Endocrine Society
Nov 10, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Andrew ToogoodBeverly M K Biller
May 8, 2013·The Journal of Clinical Endocrinology and Metabolism·Vera Popovic
Apr 23, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Marianne Andersen

❮ Previous
Next ❯

Citations

Dec 12, 2017·F1000Research·Cesar Luiz Boguszewski
Mar 13, 2017·Endocrine·Ana Beatriz Winter TavaresFlávia Lucia Conceição
Nov 26, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Kevin C J YuenAndrew R Hoffman
Jul 29, 2020·Journal of Endocrinological Investigation·L CasamitjanaA Caixàs

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.