Effects of gender on resting leg blood flow: implications for measurement of regional substrate oxidation

Journal of Applied Physiology
Michael D JensenM J Murray

Abstract

These studies were designed to examine whether the respiratory quotient (RQ) of leg tissue (primarily skeletal muscle) would increase to a greater degree in women than in men during meal ingestion. We found that mean leg and systemic RQ values were similar in men under both basal and fed conditions, whereas the agreement was poor in women. In women, leg RQ values tended to be greater than the systemic RQ, whereas splanchnic RQ values tended to be lower than the systemic RQ. The possibility that measurement imprecision accounted for the different findings in women could not be excluded because the arteriovenous blood O2 differences were almost twice as great in men as in women (53.7 +/- 5.4 vs. 28.6 +/- 2.9 ml of O2/l, respectively; P < 0.01), as were venoarterial blood CO2 differences. The smaller arteriovenous differences in women appeared to limit our ability to accurately measure their leg RQ values. O2 uptake relative to leg fat-free mass (FFM) was not different between men and women, whereas leg blood flow relative to leg FFM was greater in women than in men (55 +/- 3 vs. 39 +/- 2 ml.kg FFM-1.min-1, respectively; P < 0.001). These findings were confirmed by examining data from other studies conducted in our laboratory to c...Continue Reading

References

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Citations

Nov 9, 2002·American Journal of Physiology. Endocrinology and Metabolism·Tracy J HortonDaniel H Bessesen
Jul 17, 2003·Acta Physiologica Scandinavica·M D Jensen
Jul 12, 2007·American Journal of Physiology. Endocrinology and Metabolism·Gareth A WallisGeorge A Brooks
Oct 6, 2009·Experimental Physiology·Joep P J SchmitzJeroen A L Jeneson
Sep 8, 2009·Experimental Physiology·S S JarvisJ A Pawelczyk
Dec 31, 2015·American Journal of Physiology. Endocrinology and Metabolism·Yvo H A M Kusters, Eugene J Barrett
Oct 25, 2012·Diabetes·Eugene J Barrett, Stephen Rattigan

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