Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strains.

Behavior Genetics
John C CrabbeDouglas Wahlsten

Abstract

Mice from eight inbred strains were studied for their acute sensitivity to ethanol as indexed by the degree of hypothermia (HT), indexed as the reduction from pre-injection baseline of their body temperature. Two weeks later, mice were tested for their loss of righting reflex (LRR) after a higher dose of ethanol. The LRR was tested using the "classical" method of watching for recovery in animals placed on their backs in a V-shaped trough and recording duration of LRR. In a separate test, naive animals of the same strains were tested for HT repeatedly to assess the development of rapid (RTOL) and chronic tolerance (CTOL). We have recently developed a new method for testing LRR that leads to a substantial increase in the sensitivity of the test. Strains also have been found to differ in the new LRR test, as well as in the development of acute functional tolerance (AFT) to this response. In addition, our laboratory has periodically published strain difference data on the older versions of the HT and LRR responses. The earlier tests used some of the exact substrains tested currently, while for some strains, different substrains (usually, Nih versus Jax) were tested. We examined correlations of strain means to see whether patterns o...Continue Reading

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Citations

Oct 10, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yi-Chyan Chen, Andrew Holmes
Jul 25, 2009·Journal of Biological Rhythms·Joseph A SeggioAlan M Rosenwasser
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Feb 9, 2012·Alcoholism, Clinical and Experimental Research·John C CrabbePamela Metten
Feb 10, 2012·Alcoholism, Clinical and Experimental Research·John C CrabbePamela Metten
Jul 1, 2008·Biological Psychiatry·Ildiko RaczAndreas Zimmer
Oct 30, 2012·Pharmacology, Biochemistry, and Behavior·Stephen T Hansen, Stefan M Pulst
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Apr 23, 2008·Current Protocols in Neuroscience·John C CrabbeDouglas Wahlsten
Jun 5, 2019·Scientific Reports·Carina BoddenS Helene Richter
Aug 6, 2017·Brain Research Bulletin·Helen M KamensCarley N Miller

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