Effects of genetic polymorphisms of the renin-angiotensin system in children with nephrotic syndrome

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Yilmaz TabelEbru Yilmaz

Abstract

The renin-angiotensin system (RAS) has been considered to be responsible for the pathogenesis or progression of many diseases which may or may not be related to kidney. Genetic polymorphisms of the various components of the RAS have been associated with differences in the clinical course of several disease states in adults and children. The purpose of our study was to investigate RAS gene polymorphisms in patients with steroid resistant primary focal segmental glomerulosclerosis (FSGS) and nephrotic syndrome responding to steroid therapy. Furthermore, we aimed to investigate whether there was an association between polymorphic alleles and responses to steroid therapy, the degree of renal dysfunction, and prevalence of end-stage renal disease (ESRD). One hundred and fifty-eight children with the diagnosis of nephrotic syndrome were recruited from the Nephrology unit in the Department of Paediatrics of Ege University. Forty-nine of them were classified as renal biopsy-proven FSGS and 102 patients were considered to have response to steroid treatment. Renal functional impairment was detected in 19 subjects with FSGS and end-stage renal insufficiency in 13 patients. The control group consisted of 287 healthy adult subjects. Angiote...Continue Reading

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Citations

May 10, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hyun Jin ChoiHae Il Cheong
Jul 22, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Amy K MottlKari E North
Feb 25, 2009·Journal of Clinical Periodontology·Ali GürkanAfig Berdeli
Sep 12, 2014·Computational and Structural Biotechnology Journal·Georgia G BraliouPantelis G Bagos
Oct 19, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Tian-Biao ZhouYuan-Han Qin
May 10, 2017·Fetal and Pediatric Pathology·Maryam MonajemzadehNarjes Soleimanifar

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