Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events.

Clinical and Experimental Nephrology
Kazufumi IwataHideyuki Saito

Abstract

Susceptibility to cisplatin (CDDP) nephrotoxicity is known to vary between individuals, but the basis of this variation has not been fully elucidated. In the kidney, CDDP is taken up into the renal proximal tubular cells mainly via SLC22A2 organic cation transporter 2 (OCT2) and secreted into lumen via other transporters including SLC47A1 multidrug and toxin extrusion 1 (MATE1). Here, we explore the effect of single-nucleotide polymorphisms (SNPs) at 808G>T in OCT2 and at rs2289669 G>A in MATE1 on CDDP-induced adverse events. Fifty-three patients who had been treated with CDDP were enrolled. The plasma concentration of CDDP was measured on days 4 and 7 after treatment. The grade of hematology and nephrotoxicity was evaluated by Common Terminology Criteria for Adverse Events. In the first treatment cycle, serum creatinine (SCr) levels in the patients with OCT2 808GG and 808GT were increased by 1.43- and 1.19-fold, respectively. In the total treatment cycles, 12 patients (27 %) with 808GG experienced over grade 2 SCr elevation, whereas those with 808GT did not show any apparent nephrotoxicity. The hematological toxicity and plasma concentrations of CDDP showed no difference between patients in both groups. The rs2289669 G>A SNP i...Continue Reading

References

Jan 1, 1988·Annals of Internal Medicine·F N HutchisonG A Kaysen
Jan 1, 1995·Toxicology and Applied Pharmacology·Y K KimS H Lee
Aug 1, 1993·Gynecologic Oncology·T L Cornelison, E Reed
Jul 16, 1996·Biochemical and Biophysical Research Communications·M OkudaK Inui
Jun 1, 1996·Kidney International·J B Pritchard, D S Miller
Sep 6, 2000·Kidney International·K I InuiH Saito
Dec 12, 2001·Kidney International·J DengR A Star
Dec 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Masato OtsukaYoshinori Moriyama
Apr 11, 2008·Clinical Pharmacology and Therapeutics·I S SongJ G Shin
Jun 14, 2008·Pharmacogenetics and Genomics·Zhi-Jun WangMoses S S Chow
Jun 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kelly K FilipskiAlex Sparreboom
Jan 28, 2009·The Pharmacogenomics Journal·Ying ChenKathleen M Giacomini
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Jul 25, 2009·Clinical Pharmacology and Therapeutics·K K FilipskiA Sparreboom

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Citations

Feb 26, 2013·The AAPS Journal·Hideyuki Motohashi, Ken-ichi Inui
Sep 19, 2012·Drug Metabolism and Pharmacokinetics·Jason A SprowlAlex Sparreboom
May 1, 2013·Journal of Pharmaceutical Sciences·Hideyuki MotohashiKen-Ichi Inui
Jun 21, 2016·Advanced Drug Delivery Reviews·Fanfan ZhouMichael Murray
Jul 8, 2016·Journal of Clinical Pharmacology·Cheynne McLeanRichard B Kim
Jul 8, 2016·Journal of Clinical Pharmacology·Anna Hucke, Giuliano Ciarimboli
Oct 27, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Bhagwat PrasadJashvant D Unadkat
Jan 31, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Qing LiYan Shu
Oct 5, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yoshitaka SaitoKen Iseki
Jan 24, 2017·Advanced Drug Delivery Reviews·Blessy GeorgeLauren M Aleksunes
Aug 21, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jason A SprowlAlex Sparreboom
Feb 2, 2019·Current Topics in Medicinal Chemistry·Eleni A RekkaMaria Pantelidou
Jul 16, 2013·Current Opinion in Nephrology and Hypertension·Hermann Koepsell
Mar 1, 2018·Pharmacological Reviews·Fabian MüllerMartin F Fromm
Jan 1, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jason A Sprowl, Alex Sparreboom
Jun 21, 2015·Pharmacological Reviews·Dustin R WalshPeter A Friedman
May 21, 2013·Pharmacological Reviews·Jörg KönigMartin F Fromm
Aug 22, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Andrew W BergenGary E Swan
Apr 12, 2020·Expert Opinion on Drug Metabolism & Toxicology·Kevin M HuangAlex Sparreboom
May 27, 2016·Drug Metabolism and Personalized Therapy·Clifford JacobsMongi Benjeddou
Feb 18, 2017·Clinical Pharmacokinetics·Anton IvanyukThierry Buclin
Sep 16, 2020·International Journal of Molecular Sciences·Zulfan ZazuliRosalinde Masereeuw
Oct 16, 2018·Frontiers in Pharmacology·Zulfan ZazuliAnke-Hilse Maitland-van der Zee
May 26, 2018·Pediatric Blood & Cancer·Ryu YanagisawaTomohiko Nakamura
Dec 20, 2019·Pharmacological Reviews·Hermann Koepsell
Jun 12, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jason A SprowlAlex Sparreboom
Dec 10, 2020·Pharmacogenomics and Personalized Medicine·Linda AwdishuMelanie S Joy
Mar 23, 2021·Acta Pharmacologica Sinica·Chun-Yan FangQin-Jie Weng
Jul 30, 2019·Chemical Research in Toxicology·Luyu QiFuyi Wang
Mar 10, 2015·Molecular Pharmaceutics·Johanna J SalomonCarsten Ehrhardt

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