Effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci on the proliferation and differentiation of mouse epidermal melanocytes in serum-free culture

European Journal of Cell Biology
Tomohisa HirobeShosuke Ito

Abstract

To examine the effects of coat-color genes on the proliferation and differentiation of mouse epidermal melanocytes, we cultured epidermal, cell suspensions derived from neonatal skins of C57BL/10JHir (black) and its congenic mice carrying agouti, brown, albino, dilute, and pink-eyed dilution genes in a serum-free medium supplemented with dibutyryl adenosine 3',5'-cyclic monophosphate. The proliferative rates of agouti, brown and dilute black melanocytes were similar to that of black melanocytes, while those of albino and pink-eyed black melanocytes were about one-half of that of black melanocytes. The morphology of albino and pink-eyed black melanocytes, though nonpigmented, was similar to black melanocytes; namely, dendritic, polygonal or epithelioid. Dilute black melanocytes also possessed the similar morphology, whereas their melanosomes were accumulated in the perinuclear region. Dopa-melanin depositions after dopa reaction in brown and dilute black melanocytes were greater than in black and agouti melanocytes. Although dopa-melanin depositions were not observed in albino melanocytes, about 8% of pink-eyed black melanocytes were positive to dopa reaction. Silver depositions after combined dopa-premelanin reaction in agouti,...Continue Reading

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Citations

Aug 18, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Leslie A LyonsRobert A Grahn
Jun 26, 2001·Hearing Research·S BartelsA L Nuttall
Mar 8, 2011·Pigment Cell & Melanoma Research·Tomohisa Hirobe
Feb 26, 2011·Science·Marie ManceauHopi E Hoekstra
Jan 4, 2005·Ophthalmic Research·Rangaprasad Sarangarajan, Shireesh P Apte
May 23, 2019·Nature Communications·Phillip L ManningRoy A Wogelius
Apr 6, 2006·European Journal of Cell Biology·Tomohisa HirobeMasako Mizoguchi

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