Effects of gestation on enzymes controlling aldosterone synthesis in the rat adrenal

Endocrinology
M BrochuS Picard

Abstract

In the present study, the effects of gestation on various enzymes implicated in corticosteroid synthesis were evaluated in adrenal zona glomerulosa and zona fasciculata-reticularis of the Sprague-Dawley rat. The activity and expression of cholesterol side-chain cleavage cytochrome P450, 11beta-hydroxylase cytochrome P450, and aldosterone synthase cytochrome P450 (P450aldo) were analyzed. Plasma aldosterone levels were increased significantly at 22 days gestation (n = 10) and fell below the nonpregnant levels at 18-36 h postpartum (n = 11). The activity and expression of 11beta-hydroxylase cytochrome P450 and cholesterol side-chain cleavage cytochrome P450 were not modified by gestation. P450aldo activity increased at 14 days gestation (n = 4) and returned to the prepregnancy level at 2 weeks postpartum (n = 5). As shown by Northern blot analysis (n = 3), P450aldo messenger RNA increased significantly at 22 days gestation and decreased 18-36 h postpartum. We clearly demonstrated that elevated plasma aldosterone levels during pregnancy are associated with augmented activity and messenger RNA levels of P450aldo in the zona glomerulosa.

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Citations

Apr 20, 2011·The Journal of Obstetrics and Gynaecology Research·Ebru ZulfikarogluNuri Danisman
Jun 30, 2018·Current Opinion in Nephrology and Hypertension·Aline M A de Souza, Crystal A West
Dec 27, 2011·American Journal of Physiology. Heart and Circulatory Physiology·M ProvencherJ St-Louis
Oct 20, 2017·American Journal of Physiology. Renal Physiology·Crystal A WestMichelle L Gumz
May 1, 2015·American Journal of Physiology. Renal Physiology·Crystal A WestChris Baylis
May 20, 2000·Annals of the New York Academy of Sciences·E HassanS Michalas
Aug 12, 2015·Experimental Physiology·Crystal A WestChris Baylis
Dec 1, 2004·Kidney International·Kushiar ShojaatiMarkus G Mohaupt

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