Effects of gestational exposure to perfluorooctane sulfonate on the lung development of offspring rats.

Environmental Pollution
Huishan ZhangLeping Ye

Abstract

Perfluorooctane sulfonate (PFOS) is a man-made fluorosurfactant widely used in industry and consumer products. Previous studies with rats suggested that gestational exposure to PFOS may affect the lung development in the offspring. The mechanism, however, is still unknown. In the present study, we have exposed 24 pregnant SD rats from gestational day 12-18 to different doses of PFOS (0, 1 or 5 mg/kg BW/day). The lungs of the offspring were analyzed at postnatal days 1, 3, 7 and 14. PFOS treatment appeared to reduce the alveolar numbers, resulting in simplified alveolar structure and thickened alveolar septa. Also, PFOS treated animals had increased lung inflammation with up-regulated inflammasome associated proteins NLRP3, ASC, Caspase-1 and GSDMD and increased inflammatory cytokines IL-18 and IL-1β. At the same time, HIF-1α and VEGFA were significantly down-regulated. Since HIF-1α and VEGFA are critical factors promoting alveolar development and pulmonary angiogenesis, these results suggested that PFOS may also affect lung development by inhibiting HIF-1α and VEGFA expression. Our results here indicate that gestational exposure to PFOS may affect lung development in the offspring with pathological characteristics similar to br...Continue Reading

References

Jan 1, 1997·International Journal of Legal Medicine·P BetzW Eisenmenger
Aug 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·M JakkulaS H Abman
Apr 2, 2003·Seminars in Neonatology : SN·Jacqueline J Coalson
May 30, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher LauLisa A Stevenson
Jan 28, 2004·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Rayetta C GrastyJohn M Rogers
Oct 27, 2005·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·R C GrastyJ M Rogers
Sep 25, 2009·Chemosphere·Yi He JinShuji Tsuda
Jan 19, 2013·American Journal of Respiratory Cell and Molecular Biology·Stefanie C HummlerShu Wu
Mar 19, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Erik A Jensen, Barbara Schmidt
May 27, 2014·Cell·Mohamed Lamkanfi, Vishva M Dixit
Nov 2, 2014·Nature Reviews. Drug Discovery·Holger K EltzschigSean P Colgan
Nov 5, 2014·Environmental Science and Pollution Research International·Tao ZhangKurunthachalam Kannan
Apr 17, 2015·Immunological Reviews·Ine Jorgensen, Edward A Miao
Jun 9, 2015·Seminars in Pediatric Surgery·Dhanya Mullassery, Nicola P Smith
Nov 15, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Eun Jun YunThiennu H Vu
Nov 9, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Zhenwei LiJing Shao
Dec 17, 2016·Cell·Junying YuanBénédicte F Py
Dec 28, 2016·Environmental Pollution·Meng-Shan TsaiPau-Chung Chen
Feb 1, 2017·Nature Reviews. Immunology·Ine JorgensenEdward A Miao
Feb 9, 2017·Environmental Research·Xiao-Di QinGuang-Hui Dong
Jun 28, 2017·Environmental Science & Technology·Keng Po LaiChris Kong-Chu Wong
Sep 2, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dietmar SpenglerMartin F Krause
Nov 15, 2017·Occupational and Environmental Medicine·Ying LiKristina Jakobsson
Jun 13, 2019·Scientific Reports·Leanna NguyenClyde J Wright
Sep 20, 2019·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jorid B SørliBirgitte Lindeman

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