Effects of ghrelin treatment on exertional dyspnea in COPD: an exploratory analysis

The Journal of Physiological Sciences : JPS
Keisuke MikiKenji Kangawa

Abstract

A substudy of ghrelin treatment in a multicenter trial previously revealed that administration of ghrelin improves the exercise capacity of underweight COPD patients. To clarify exertional dyspnea more precisely, exploratory analysis was conducted on data from the substudy. Of 20 underweight COPD patients who were randomized to pulmonary rehabilitation with intravenous ghrelin (2 μg/kg, n = 10) or placebo (n = 10) twice daily for 3 weeks in the substudy, 16 (ghrelin = 9, placebo = 7) could be investigated for dyspnea break-point on the dyspnea-ratio (%) of Δoxygen uptake ([Formula: see text]) (= peak minus resting [Formula: see text]) curve. A significant treatment effect of ghrelin on percentage [Formula: see text] at the dyspnea break-point to Δ[Formula: see text] (p = 0.049) was achieved. In conclusion, underweight COPD patients benefitted from ghrelin treatment in terms of shifts to the early exercise phase of the dyspnea break-point during a standardized exercise program.

References

Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·D E O'DonnellK A Webb
Mar 1, 1997·Journal of Applied Physiology·W W StringerK Wasserman
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·C LandboT P Almdal
Nov 1, 2000·Nature·M TschöpM L Heiman
Feb 24, 2001·Nature·M NakazatoS Matsukura
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·N NagayaK Kangawa
Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Denis E O'DonnellKatherine A Webb
Nov 2, 2002·Hypertension·Kiyoshi MatsumuraMitsuo Iida
Sep 16, 2005·Chest·Noritoshi NagayaKenji Kangawa
Mar 4, 2008·The European Respiratory Journal·P D Wagner
May 20, 2009·Respiratory Physiology & Neurobiology·Denis E O'DonnellDennis Jensen
Sep 11, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Keisuke MikiMasaharu Motone
Jan 21, 2010·The Journal of Physiological Sciences : JPS·Keisuke MikiMasaharu Motone
Nov 6, 2010·Chest·Nausherwan K Burki, Lu-Yuan Lee
Oct 20, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Keisuke MikiYoshitaka Tateishi
Jul 24, 2012·American Journal of Respiratory and Critical Care Medicine·Philippe GagnonFrançois Maltais
Dec 14, 2012·Expert Review of Respiratory Medicine·Pierantonio LavenezianaDenis E O'Donnell
Dec 19, 2012·Respiratory Physiology & Neurobiology·Keisuke MikiMasahide Mori
Dec 29, 2013·Respiratory Physiology & Neurobiology·Karlman WassermanKathy E Sietsema

❮ Previous
Next ❯

Citations

Apr 12, 2017·International Journal of Molecular Sciences·Gustav ColldénTimo D Müller
Mar 1, 2018·Chronic Respiratory Disease·Xue ZhangLei Chen
Nov 5, 2017·Respiratory Research·Nazareth de Novaes RochaPatricia Rieken Macedo Rocco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.