Effects of ginseng total saponin on morphine-induced hyperactivity and conditioned place preference in mice

Journal of Ethnopharmacology
H S KimW K Park

Abstract

A single or repeated administration of morphine in mice produced hyperactivity, conditioned place preference (CPP) and postsynaptic dopamine (DA) receptor supersensitivity. The hyperactivity induced by morphine was evidenced by measuring the enhanced ambulatory activity using a tilting-type ambulometer. CPP effects were evaluated assessing the increased time spent by the mice to morphine and the inhibition of CPP by the decreased time spent by the mice in the white compartment. Postsynaptic DA receptor supersensitivity in mice displaying a morphine-induced CPP was evidenced by the enhanced response in ambulatory activity to the DA agonist, apomorphine (2 mg/kg, s.c.). The intraperitoneal injection of ginseng total saponin (GTS) from the root of Panax ginseng C.A. Meyer (Araliaceae), prior to and during the morphine treatment in mice inhibited morphine-induced hyperactivity and CPP. GTS inhibited the development of postsynaptic DA receptor supersensitivity. A single dose administration of GTS also inhibited apomorphine-induced climbing behavior, showing the antidopaminergic action of GTS at the postsynaptic DA receptor. These results suggest that the development of morphine-induced CPP may be associated with the enhanced DA rece...Continue Reading

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Citations

Dec 30, 1998·Archives of Pharmacal Research·H S KimM K Lee
Oct 11, 2005·Archives of Pharmacal Research·Hyoung-Chun KimKi-Wan Oh
Dec 9, 2003·European Journal of Pharmacology·Mohammad-Reza ZarrindastAli Haeri-Rohani
Sep 21, 2002·Journal of Ethnopharmacology·Thangarajan SumathiSivasithamparam Niranjali Devaraj
Aug 4, 1999·Journal of Ethnopharmacology·H S KimM K Lee
Jun 27, 1998·The Journal of Pharmacy and Pharmacology·H S KimC G Jang
Aug 25, 2004·Journal of Ethnopharmacology·S G SpargJ van Staden
Apr 6, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·S Tokuyama, M Takahashi
Mar 1, 2012·Biomolecules & Therapeutics·Hye Jin ChaEun Jung Kim

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