Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats

Toxicology
Qi-Yu YangJia-Dan Yang

Abstract

Ginsenoside Rg3 (Rg3) is one of the key components of a frequently used herbal tonic panax ginseng for fatigue treatment. However, the molecular mechanisms of Rg3 on anti-fatigue effects have not been completely understood yet. We built a postoperative fatigue syndrome (POFS) model and tried to elucidate the molecular mechanisms responsible for anti-fatigue effects of Rg3. 160 aged male rats were randomly divided into four groups (n = 40/group): normal group, Rg3-treated normal group (Rg3 group), postoperative fatigue syndrome model group (POFS group) and Rg3-treated postoperative fatigue syndrome model group (POFS + Rg3 group). The open field test (OFT) was used to assess general activity and exploratory behavior of rats in different groups. We then analyzed total cholesterol (TC), serum triglyceride (TG) and lactate dehydrogenase (LDH) in the blood, as well as superoxide dismutase (SOD), malondialdehyde (MDA), peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression in skeletal muscles of rats. We also detected the influence of Rg3 on silent information regulator of transcription 1 (sirtuin1, SIRT1) activity and protein 53 (p53) transcriptional acti...Continue Reading

Citations

Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eun Ju ShinYoungkyung Rhee
May 8, 2019·Current Vascular Pharmacology·Wenqian ZhangYouhua Xu
Jun 1, 2019·Journal of Medicinal Food·Victor Myung Joon BangElen Landgraf Guiguer
Oct 7, 2020·Critical Reviews in Food Science and Nutrition·Liyi WangTizhong Shan
Nov 16, 2020·Journal of Ethnopharmacology·Mengjiao HeChunchao Han
Dec 5, 2020·Journal of Ethnopharmacology·Tingting LouXiangyan Li
Apr 23, 2020·Mechanisms of Ageing and Development·Patricia S Pardo, Aladin M Boriek

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