Effects of ginsenosides extracted from ginseng stem and leaves on glucocorticoid receptor in different viscera in heat-damaged rats

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Min LiZhi-Lei Shen

Abstract

To evaluate the effects of ginsenosides (GSS) extracted from ginseng stem and leaves on glucocorticoid receptor (GR) in different viscera in heat-damaged rats, and to find out its action mechanism. Thirty-two male SD rats were divided into control group and experimental group, and fed 2 mg/d GSS and equal-quantity of distilled water respectively for 7 days. Eight rats of each group were exposed to (42+/-1) degrees C for one hour. The binding activities of GR in brain, thymus, lung and liver cytosols in rats were detected by radioligand binding assay. The expression levels of GR mRNA in brain and liver cytosols were determined by reverse transcription-polymerase chain reaction (RT-PCR) assay. Plasma adrenocorticotropin (ACTH) and corticosterone (CS) concentrations were determined by radioimmunoassay. The binding activities of GR in brain, lung and liver cytosols, and the expression levels of GR mRNA in brain and liver cytosols were all higher in the GSS-treated and heat-damaged rats than those in the untreated heat-damaged rats (P<0.05 or P<0.01). There were no significant differences in plasma concentrations of ACTH and CS between the GSS-treated heat-damaged rats and the untreated heat-damaged rats. GSS can lessen the descendi...Continue Reading

References

Aug 23, 2005·Vitamins and Hormones·Dapei Li, Edwin R Sánchez

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Citations

Feb 17, 2009·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Feng YingluChen Zhe
Oct 24, 2009·Chinese Medicine·Hongwei WangJingtian Xie
Feb 17, 2009·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Xiang LuBai Li
Aug 24, 2010·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Yan-li YouChang-quan Ling
Apr 29, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Yinglu FengChangquan Ling

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