Effects of ginsenosides on impaired performance induced in the rat by scopolamine in a radial-arm maze

Psychoneuroendocrinology
Y YamaguchiH Kobayashi

Abstract

The effects of ginsenosides Rg1, Rd and Rb1 on impaired performance induced in the rat by scopolamine were examined in a radial-arm maze. Scopolamine caused a reduction in the number of initial correct responses in the maze. A single IP injection of Rg1, but not Rd or Rb1, prevented the reduction. The inhibition of the reduction in initial correct responses was associated with a bell-shaped dose-response curve for Rg1. A lesion in the medial septum caused spatial learning deficits. Rg1 did not overcome these deficits. It is suggested that cholinergic neurons in the medial septum are involved in the ameliorative effect of Rg1 on impaired performance induced by scopolamine.

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Citations

Apr 19, 2005·Archives of Pharmacal Research·Hai Ying BaoJong Seong Kang
Sep 26, 1996·European Journal of Pharmacology·Y YamaguchiH Kobayashi
Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·David O Kennedy, Andrew B Scholey
Jun 19, 1998·Neuroreport·R Zhao, W F McDaniel
Jul 19, 2006·International Immunopharmacology·Jue-Hee Lee, Yongmoon Han
Nov 26, 1999·Biochemical Pharmacology·A S AtteleC S Yuan
Jul 23, 2015·Journal of Ginseng Research·Yeonju Lee, Seikwan Oh
Nov 2, 2016·Food & Function·Jisun Oh, Jong-Sang Kim
May 13, 2006·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Soo Jung ChoiDong Hoon Shin
Jun 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jianbo ChenYinshi Sun
Mar 18, 2009·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Soo Jung ChoiDong-Hoon Shin

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