Effects of glatiramer acetate on spasticity in previously interferon-beta-treated and treatment-naive patients with relapsing-remitting multiple sclerosis: a prospective, nonrandomized, open-label, uncontrolled, observational pilot study

Clinical Therapeutics
J E Meca-LallanaAndrés Fernández Barreiro

Abstract

Treatment with interferon-beta (IFN-beta) has been related to worsening of muscle spasticity in patients with multiple sclerosis (MS). However, there are no specific data on the effects of glatiramer acetate (GA) on spasticity. The aim of the present study was to assess the effects of GA on spasticity in patients with relapsing-remitting MS who had been previously treated with IFN-beta or were treatment naive. Two cohorts of MS patients with spasticity who were about to begin treatment with GA at the approved dosage (20 mg/d) were enrolled in the study: patients who were being switched from IFN-beta due to adverse events or lack of efficacy (cohort 1) and patients who were treatment naive (cohort 2). The follow-up periods for cohorts 1 and 2 were 18 and 12 months, respectively. Patients' physical condition was assessed at baseline and at the end of follow-up using the Modified Ashworth Scale (MAS), Penn Spasm Frequency Scale (PSFS), Global Pain Score (GPS), Adductor Tone Rating Scale, Expanded Disability Status Scale (EDSS), and neurophysiologic tests (latency and amplitude of the Hoffmann reflex [H reflex] in the soleus, and ratio of maximum H reflex to maximum motor response [H/M ratio] in the lower limb). The frequency and s...Continue Reading

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Citations

Jun 1, 2011·Drug Design, Development and Therapy·Richard NicholasPaolo A Muraro
May 25, 2012·Disability and Rehabilitation·Justin N CheeKarl F Zabjek
Oct 9, 2015·Brain and Behavior·Jose Eustasio Meca-LallanaEster Carreón-Guarnizo
Mar 16, 2011·Journal of Biomedicine & Biotechnology·Louise LarocqueXuguang Li
Mar 1, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Deepak M W BalakH Bing Thio
Oct 20, 2011·Therapeutic Advances in Neurological Disorders·Aaron BosterMichael Racke
Jan 1, 2012·Journal of Central Nervous System Disease·Oscar Fernández
Sep 29, 2019·Drug and Therapeutics Bulletin·Matthew Roughley, Marc Lyall
May 3, 2011·Current Opinion in Neurology

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