PMID: 1200153Nov 1, 1975Paper

Effects of glucagon and insulin on net hepatic metabolism of glucose precursors in sheep

The American Journal of Physiology
R P BrockmanJ G Manns

Abstract

The net hepatic metabolism of amino glycerol, lactate, and pyruvate was determined in conscious fed sheep by multiplying the venoarterial concentration differences by the hepatic blood or plasma flow. In each experiment several sets of control blood samples were taken; glucagon or insulin then was infused intraportally for 2 h during which additional samples were taken. Four types of experiments were performed: 1) glucagon infusion (150 mug/h) into normal sheep, 2) glucagon infusion (100 mug/h) into insulin-treated alloxanized sheep, 3) insulin infusion (1.17 U/h) into normal sheep, and 4) insulin plus glucose infusion (12.3 mmol/h) into normal sheep. The second group of experiments was performed to prevent reflex hyperinsulinemia, and the fourth was performed to prevent reflex hyperglucagonemia. Glucagon directly stimulated the net hepatic uptake of alanine, glycine, glutamine, arginine, asparagine, threonine, serine, and lactate. Glucagon also stimulated lipolysis in adipose tissue. Insulin, on the other hand, appeared to have a lipogenic effect on adipose tissue and to stimulate directly the uptake of valine, isoleucine, leucine, tyrosine, lysine, and alanine only at extrahepatic sites. The study showed that, in sheep, the e...Continue Reading

Citations

Jun 1, 1983·The Proceedings of the Nutrition Society·P J Buttery
Jun 1, 1982·Journal of Dairy Science·B LaarveldD E Kerr
Dec 9, 1997·The British Journal of Nutrition·K Holtenius, P Holtenius
Oct 13, 2000·The British Journal of Nutrition·T ObitsuG E Lobley
Jul 5, 2013·Animal : an International Journal of Animal Bioscience·M Larsen, N B Kristensen
Dec 1, 1978·The Proceedings of the Nutrition Society·J M Bassett
Jun 1, 2010·Journal of Neurosurgery·Rami Abu FanneAbd Al-Roof Higazi
Jun 17, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rami Abu FanneAbd Al-Roof Higazi
Feb 1, 1984·Zeitschrift für Tierphysiologie, Tierernährung und Futtermittelkunde·T MotylW Kukulska
Sep 1, 1985·The British Journal of Nutrition·A N JanesD G Armstrong
Jan 19, 1999·Journal of Dairy Science·M D HaniganJ L Beckett
Jan 1, 1988·Annals of the New York Academy of Sciences·T J McDonaldI M Hramiak
Jul 1, 1989·The British Journal of Nutrition·M E SymondsM A Lomax
Nov 10, 2001·American Journal of Physiology. Endocrinology and Metabolism·J D HouseJ T Brosnan
Jun 15, 2006·The Journal of Nutrition·Barry J BradfordMichael S Allen
Apr 1, 1985·The American Journal of Physiology·M A DavisA D Cherrington
Mar 1, 1996·Domestic Animal Endocrinology·S M Francis, R Bickerstaffe
Feb 23, 1999·Kidney International·M StumvollJ Gerich
Jan 1, 1980·Progress in Lipid Research·R G Vernon
Dec 1, 1981·Biochemical Medicine·C Mohan, S P Bessman
Apr 20, 2004·Journal of Theoretical Biology·M D HaniganJ France
Dec 1, 1981·Metabolism: Clinical and Experimental·J E LiljenquistW W Lacy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.