Effects of glucocorticoid therapy on urine protein-to-creatinine ratios and renal morphology in dogs

Journal of Veterinary Internal Medicine
C B WatersM Gasparini

Abstract

Glomerulonephritis has been associated with exogenous glucocorticoid administration and spontaneous hyperadrenocorticism in the dog. The purpose of this study was to determine the effects of long-term glucocorticoid therapy on urine protein:creatinine ratios (UP/Cs) and renal morphology. Nine young-adult male dogs were determined to be healthy and have normal renal function as assessed by physical examination, CBC, serum biochemistry analysis, Knott's test for Dirofilaria immitis, urinalysis, urine culture, urine protein electrophoresis, endogenous creatinine clearance, 24-hour urinary protein excretion, and UP/C. Prednisone was administered to each dog at a dosage of 2.2 mg/kg PO bid for 42 days. Urinalysis and UP/C were performed on days 0, 7, 14, 21, 28, and 42 of treatment. Mean UP/C on day 0 was 0.29 +/- 0.10. Mean UP/C increased progressively to a maximum of 1.27 +/- 1.02 on day 28. Mean UP/C on day 42 decreased slightly (0.92 +/- 0.56) but remained significantly increased above baseline. The most consistent renal light microscopic finding on necropsy examination was generalized hypercellular glomerular tufts, suggestive of mesangial cell proliferation. Four dogs also had occasional adhesions of glomerular tufts to Bowman...Continue Reading

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Citations

Mar 19, 2011·Journal of Feline Medicine and Surgery·Brianna BacklundGeorge E Lees
Feb 19, 2003·Research in Veterinary Science·S D ForresterD L Ward
Feb 22, 2008·Journal of Veterinary Internal Medicine·L A CohnC R Reinero
Mar 4, 2008·Journal of Veterinary Internal Medicine·S SchellenbergC E Reusch
Jan 25, 2012·Journal of Veterinary Internal Medicine·K J BaxterM B Tompkins
Jul 26, 2011·Topics in Companion Animal Medicine·Shelly L Vaden
Jan 22, 2011·The Veterinary Clinics of North America. Small Animal Practice·Meryl P Littman
Jul 27, 2010·General and Comparative Endocrinology·Pascale SmetsSylvie Daminet
Jan 3, 2013·The Journal of Small Animal Practice·A Di BellaS M North
Apr 16, 2014·Veterinary Clinical Pathology·Karen M TefftLeeAnn Pack
Nov 25, 2016·Renal Failure·Wael M Elsaed, Hazem Abdelhamid Mohamed
Mar 20, 2004·The Journal of Veterinary Medical Science·Eun-Wha Choi, Chang-Woo Lee
Feb 17, 2001·Breast Cancer : the Journal of the Japanese Breast Cancer Society·S Kato
Dec 7, 2011·Systems Biology in Reproductive Medicine·Fugui FangXiaorong Zhang
Nov 26, 2015·The Journal of Veterinary Medical Science·Akira YabukiOsamu Yamato
May 7, 2016·Journal of Veterinary Internal Medicine·S S TjostheimT J Stein
Apr 3, 2018·The Journal of Small Animal Practice·R A PrudicA C Bugbee
Oct 28, 2020·The Journal of Small Animal Practice·X RouraA Zatelli
Feb 27, 2021·The Journal of Small Animal Practice·M KuijlaarsA McBrearty

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