Effects of glucocorticoids on prostaglandin formation by human amnion

Canadian Journal of Physiology and Pharmacology
W Gibb, J C Lavoie

Abstract

The human amnion may be an important source of prostaglandins involved in the onset of human labor and therefore it is important to define the factors that regulate their formation in this tissue. In the present study we demonstrate that glucocorticoids inhibit prostaglandin production by freshly isolated amnion cells. The inhibitory action of the glucocorticoids, however, changes to a stimulatory action when the cells are maintained in primary culture for a few days. For both inhibition and stimulation, concentrations of 10(-8) M dexamethasone or greater were required to give significant effects, and estradiol and progesterone had no effect on the prostaglandin output of the cells. Epidermal growth factor (EGF), which has previously been found to stimulate prostaglandin output by confluent amnion cells, did not alter prostaglandin output of cells initially placed in culture. Furthermore, the stimulatory action of EGF and dexamethasone appeared additive. The calcium ionophore A23187 stimulated prostaglandin output in freshly isolated cells and accentuated the inhibitory effect of dexamethasone. These studies indicate that prostaglandin formation by human amnion during pregnancy could be regulated by glucocorticoids. These stero...Continue Reading

Citations

May 27, 1999·Journal of Perinatal Medicine·J R ChallisF Pomini
Oct 21, 2000·Endocrine Reviews· Challis JRGS J Lye
May 19, 2012·Equine Veterinary Journal. Supplement·J C Ousey, A L Fowden
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Nov 5, 1997·Annals of the New York Academy of Sciences·J R ChallisW Gibb
Jul 24, 1998·Annals of Medicine·W Gibb
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Nov 1, 1993·General Pharmacology·T Wilson
Jan 9, 2004·Survey of Ophthalmology·Harminder S DuaV Senthil Maharajan
Dec 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Tamsin Lindstrom, Phillip Bennett

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