Effects of glucose-6-phosphate dehydrogenase deficiency upon sickle cell anaemia.

Annals of Clinical Biochemistry
A K al-AliM al-Awami

Abstract

The levels of glycated haemoglobin, fetal haemoglobin and methaemoglobin in 618 Saudi subjects were determined. A statistically significant decrease in the percentage of glycated haemoglobin was observed in all haemoglobinopathic groups studied in comparison to normal controls. However, there was no significant difference in the percentage of glycated haemoglobin in patients with sickle cell anaemia when compared with those sickle cell subjects who were also glucose-6-phosphate dehydrogenase deficient. This suggests that there is little survival advantage or disadvantage in the combination of glucose-6-phosphate dehydrogenase deficiency and sickle cell anaemia.

References

Oct 1, 1976·The Journal of Clinical Investigation·J F FitzgibbonsR T Jones
Jan 1, 1985·Annual Review of Biophysics and Biophysical Chemistry·C T Noguchi, A N Schechter
Dec 2, 1972·Lancet·R P PerrineA May
Feb 1, 1974·Annals of Internal Medicine·M H Steinberg, B J Dreiling
Apr 11, 1974·The New England Journal of Medicine·E BeutlerC West
May 1, 1984·American Journal of Hematology·M M Elseweidy, E C Abraham
Dec 12, 1959·Nature·K BETKEI SCHLICHT

❮ Previous
Next ❯

Citations

Sep 22, 2018·Current Opinion in Hematology·Matthew S KarafinRichard O Francis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.